26130
3-Chloropropionaldehyde diethylacetal
technical, ≥90% (GC)
Synonym(s):
3-Chloro-1,1-diethoxypropane
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About This Item
Linear Formula:
ClCH2CH2CH(OC2H5)2
CAS Number:
Molecular Weight:
166.65
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
252-623-4
Beilstein/REAXYS Number:
1698609
MDL number:
grade
technical
Quality Level
assay
≥90% (GC)
contains
~0.5% CaCO3 as stabilizer
refractive index
n20/D 1.42 (lit.), n20/D 1.420
bp
84 °C/25 mmHg (lit.)
density
0.995 g/mL at 25 °C (lit.)
storage temp.
2-8°C
SMILES string
CCOC(CCCl)OCC
InChI
1S/C7H15ClO2/c1-3-9-7(5-6-8)10-4-2/h7H,3-6H2,1-2H3
InChI key
NXHONHDWVLPPCS-UHFFFAOYSA-N
Application
3-Chloropropionaldehyde diethylacetal has been used in the synthesis of:
- N-[4-[[3-(2, 4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino]benzoyl]-L-glutamic acid, an acyclic analog of 5,6,7,8-tetrahydrofolic acid
- 1-(D,L)-(3′-amino, 3′-carboxypropyl)uracil, nucleoamino acid
- 7-methoxychromanone
- grignard reagent
Other Notes
Masked 3-chloropropionaldehyde; preparation of Grignard reagent
signalword
Warning
hcodes
Hazard Classifications
Flam. Liq. 3
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
129.2 °F - closed cup
flash_point_c
54 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Regulatory Information
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J L Kelley et al.
Journal of medicinal chemistry, 33(2), 561-567 (1990-02-01)
The synthesis and biological evaluation of N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino]- benzoyl]-L-glutamic acid (1) (5-DACTHF, 543U76), an acyclic analogue of 5,6,7,8-tetrahydrofolic acid (THFA), are described. The key intermediate, hemiaminal 8, was prepared in four stages from 3-chloropropionaldehyde diethyl acetal. Reaction of 8 with dimethyl
An Efficient Preparation of 7-Methoxychromanone.
Cao Z and Liehr JG.
Synthetic Communications, 26(6), 1233-1245 (1996)
Masoomeh Shirzad et al.
Assay and drug development technologies, 17(5), 231-239 (2019-05-14)
This study aimed to synthesize methoxy polyethylene glycol propionaldehyde (mPEG20,000-ALD) for the preparation of PEGylated nanoliposomal cisplatin. Nanocarriers such as liposomes are developed for a wide range of drug delivery systems. PEG with high molecular weight (Mw) is used to