261394
1,1-Dimethylurea
99%
Synonym(s):
N,N-Dimethylurea
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About This Item
Linear Formula:
(CH3)2NCONH2
CAS Number:
Molecular Weight:
88.11
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
209-957-0
MDL number:
Assay:
99%
Form:
solid
InChI key
YBBLOADPFWKNGS-UHFFFAOYSA-N
InChI
1S/C3H8N2O/c1-5(2)3(4)6/h1-2H3,(H2,4,6)
SMILES string
CN(C)C(N)=O
assay
99%
form
solid
mp
178-183 °C (lit.)
solubility
water: soluble 5%, clear, colorless
functional group
amine
Quality Level
Gene Information
human ... EPHX2(2053)
mouse ... Ephx2(13850)
Related Categories
General description
Nonlinear optical properties of 1,1-dimethylurea (N,N′ dimethylurea), have been evaluated through second-harmonic generation.
Application
1,1-Dimethylurea (N,N-dimethylurea) has been used in the Dowex-50W ion exchange resin-promoted synthesis of N,N′-disubstituted-4-aryl-3,4-dihydropyrimidinones.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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K Yamada et al.
Acta endocrinologica, 128(4), 379-384 (1993-04-01)
We investigated the effect of free radical scavengers on the actions of cytokines on islet cells. Interferon-gamma and tumor necrosis factor-alpha reduced the nicotinamide adenine dinucleotide content of mouse islet cells; the combination of interferon-gamma (4 x 10(5) U/l) and
Wanli Lu et al.
Chemistry & biology, 18(4), 425-431 (2011-04-26)
Pactamycin, one of the most densely functionalized aminocyclitol antibiotics, has pronounced antibacterial, antitumor, antiviral, and antiplasmodial activities, but its development as a clinical drug was hampered by its broad cytotoxicity. Efforts to modulate the biological activity by structural modifications using
S Sandler et al.
Endocrinology, 124(3), 1492-1501 (1989-03-01)
This study aimed at a more detailed characterization of the mechanisms by which interleukin 1 (IL-1) inhibits insulin secretion. For this purpose, isolated rat pancreatic islets were kept in tissue culture for 5 days in medium RPMI 1640 plus 10%
C J Beehler et al.
The Journal of laboratory and clinical medicine, 123(1), 73-80 (1994-01-01)
Dimethylthiourea (DMTU) is a small, highly diffusible molecule that effectively scavenges toxic oxygen metabolites in vitro and reduces oxidative injury in many biologic systems. Nonetheless, for unknown reasons, DMTU has occasionally failed to decrease damage in some systems where injury
G P Meshram et al.
Mutation research, 279(4), 275-280 (1992-06-16)
Methyl isocyanate (MIC) in aqueous solution forms methylamine (MA) and N,N'-dimethylurea (DMU). MA in buffered system further converts into its salt form, methylamine hydrochloride (MAH). Therefore, MAH and DMU were evaluated for their mutagenic activity in the in vitro Ames
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