261769
8-Methylquinoline
97%
Synonym(s):
o-Toluquinoline
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About This Item
Empirical Formula (Hill Notation):
C10H9N
CAS Number:
Molecular Weight:
143.19
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
210-264-0
Beilstein/REAXYS Number:
111340
MDL number:
Assay:
97%
Form:
liquid
InChI key
JRLTTZUODKEYDH-UHFFFAOYSA-N
InChI
1S/C10H9N/c1-8-4-2-5-9-6-3-7-11-10(8)9/h2-7H,1H3
SMILES string
Cc1cccc2cccnc12
assay
97%
form
liquid
refractive index
n20/D 1.614 (lit.)
bp
143 °C/34 mmHg (lit.)
mp
−80 °C (lit.)
density
1.052 g/mL at 25 °C (lit.)
Quality Level
General description
Tumorigenic potential of 8-methylquinoline has been evaluated in newborn CD-1 mice and Sprague-Dawley rats.
Application
8-Methylquinoline has been used in preparation of osmium chloridophosphine complexes, as quinoline carbene tautomers.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
221.0 °F - closed cup
flash_point_c
105 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Regulatory Information
危险化学品
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Kate B McMurtrey et al.
Organic letters, 14(16), 4094-4097 (2012-08-01)
The palladium-catalyzed C-H fluorination of 8-methylquinoline derivatives with nucleophilic fluoride is reported. This transformation involves the use of AgF as the fluoride source in combination with a hypervalent iodine oxidant. Both the scope and mechanism of the reaction are discussed.
Synthetic routes to N-heterocyclic carbene complexes: pyridine-carbene tautomerizations.
Doris Kunz
Angewandte Chemie (International ed. in English), 46(19), 3405-3408 (2007-04-05)
Kami L Hull et al.
Journal of the American Chemical Society, 128(22), 7134-7135 (2006-06-01)
This communication describes the development of a new Pd-catalyzed method for the fluorination of carbon-hydrogen bonds. A key step of these transformations involves palladium-mediated carbon-fluorine coupling-a much sought after, but previously unprecedented, transformation. These reactions were successfully achieved under oxidative
R Yang et al.
Luminescence : the journal of biological and chemical luminescence, 16(2), 129-133 (2001-04-20)
8-Methylquinoline is unique among the monomethylquinolines in the red-shift it shows in the absorption band derived from the short axis polarized ((1)L(a) <-- (1)A) electronic transition, relative to that in quinoline itself. The effect is even more pronounced in the
C E Scharping et al.
Carcinogenesis, 14(5), 1041-1047 (1993-05-01)
The hepatic microsomal metabolism of the carcinogenic 8-methylquinoline (8MQ) and its noncarcinogenic isomer, 6-methylquinoline (6MQ), were compared for preparations from control rats and rats pretreated with phenobarbital or 3-methylcholanthrene. For each compound the alcohol was the major metabolite, constituting 50-75%
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