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Merck
CN

271462

Dihydrofolic acid dihydrate

90%

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About This Item

Empirical Formula (Hill Notation):
C19H21N7O6 · 2H2O
CAS Number:
Molecular Weight:
479.44
UNSPSC Code:
12352100
PubChem Substance ID:
MDL number:
Assay:
90%
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InChI

1S/C19H21N7O6.2H2O/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28;;/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30);2*1H2/t12-;;/m0../s1

SMILES string

O.O.NC1=NC(=O)C2=C(NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=N2)N1

InChI key

UOHHAQNWTOGSOL-LTCKWSDVSA-N

assay

90%

Application

Dihydrofolic acid dihydrate may be used in chemical synthesis studies.

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Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Bong Gyun Kim et al.
Biotechnology progress, 32(6), 1539-1546 (2016-09-01)
Adaptation of dihydrofolate reductase (DHFR)-deficient Chinese hamster ovary (CHO) DG44 cells to chemically defined suspension culture conditions is a time-consuming and labor-intensive process because nonadapted DHFR-deficient CHO DG44 cells normally show poor growth in chemically defined medium (CDM). We examined

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