271810
4-Chloro-DL-phenylalanine methyl ester hydrochloride
99%
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About This Item
Linear Formula:
ClC6H4CH2CH(NH2)CO2CH3·HCl
CAS Number:
Molecular Weight:
250.12
EC Number:
238-024-0
UNSPSC Code:
12352103
MDL number:
assay
99%
mp
186-189 °C (lit.)
SMILES string
Cl.COC(=O)C(N)Cc1ccc(Cl)cc1
InChI
1S/C10H12ClNO2.ClH/c1-14-10(13)9(12)6-7-2-4-8(11)5-3-7;/h2-5,9H,6,12H2,1H3;1H
InChI key
GCBCWTWQAFLKJG-UHFFFAOYSA-N
Biochem/physiol Actions
Tryptophan hydroxylase inhibitor.
Tryptophan hydroxylase inhibitor. Crosses blood brain barrier better than p−chlorophenylalanine.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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K Linnet et al.
Brain research, 697(1-2), 251-253 (1995-10-30)
In order to study the impact of serotonin depletion on gene expression of the serotonin transporter (5-HTt) we measured 5-HTt mRNA levels by Northern blot in rats treated with p-chlorophenylalanine methyl ester (PCPA) for 10 days. Six rats received PCPA
P Chen et al.
Pancreas, 13(2), 147-153 (1996-08-01)
The biological significance and function of pancreatitis-associated protein (PAP), identified in 1984 as a new secretory protein appearing during pancreatitis, remain to be elucidated. The purpose of this study was to evaluate the presence of PAP in pancreatic tissue upon
M Matsukawa et al.
Neuroscience letters, 230(1), 13-16 (1997-07-11)
Treatment with serotonin and acetylcholine depletors reduced the number of synapses in the rat hippocampus. Animals that received the drug treatment lost a substantial number of synapses and showed an apparent impairment in memory acquisition. Although the animals were behaviorally