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Merck
CN

275778

Imidazo[1,2-a]pyridine

99%

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About This Item

Empirical Formula (Hill Notation):
C7H6N2
CAS Number:
Molecular Weight:
118.14
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
99%
Form:
liquid
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Product Name

Imidazo[1,2-a]pyridine, 99%

InChI

1S/C7H6N2/c1-2-5-9-6-4-8-7(9)3-1/h1-6H

SMILES string

c1ccn2ccnc2c1

InChI key

UTCSSFWDNNEEBH-UHFFFAOYSA-N

assay

99%

form

liquid

refractive index

n20/D 1.626 (lit.)

bp

103 °C/1 mmHg (lit.)

density

1.165 g/mL at 25 °C (lit.)

Quality Level

General description

In vivo anti-trypanosomal activity of imidazo[1,2-a]pyridiness in the STIB900 mouse model has been investigated.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


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Martina Hieke et al.
Bioorganic & medicinal chemistry letters, 22(5), 1969-1975 (2012-02-14)
A novel class of 5-lipoxygenase (5-LO) inhibitors characterized by a central imidazo[1,2-a]pyridine scaffold, a cyclohexyl moiety and an aromatic system, is presented. This scaffold was identified in a virtual screening study and exhibits promising inhibitory potential on the 5-LO. Here
Kyle A Emmitte et al.
Bioorganic & medicinal chemistry letters, 19(3), 1004-1008 (2008-12-23)
The optimization of imidazo[1,2-a]pyridine inhibitors as potent and selective inhibitors of IGF-1R is presented. Further optimization of oral exposure in mice is also discussed. Detailed selectivity, in vitro activity, and in vivo PK profiles of an optimized compound is also
Yoshito Terao et al.
Bioorganic & medicinal chemistry letters, 22(24), 7326-7329 (2012-11-14)
Imidazo[1,2-a]pyridine derivatives were designed, synthesized, and evaluated as inhibitors of the apoptosis signal-regulating kinase 1 (ASK1). These were based on a benzothiazole derivative that was discovered from high-throughput screening of our compound library. As a result, we identified potent, selective
Joanna M Wisniewska et al.
Biochemical pharmacology, 83(2), 228-240 (2011-10-27)
5-Lipoxygenase (5-LO) is a crucial enzyme of the arachidonic acid (AA) cascade and catalyzes the formation of bioactive leukotrienes (LTs) which are involved in inflammatory diseases and allergic reactions. The pathophysiological effects of LTs are considered to be prevented by
Enza Palazzo et al.
Neuropharmacology, 58(3), 660-667 (2009-12-01)
The 6-methoxy-2-phenylimidazo[1,2-b]pyridazine-3-carboxylic acid, DM2, exerts anti-absence activity and blocks Cav3.1 channel, a T-type voltage-dependent Ca(2+) channel subtype, in vitro. The current study investigated the effect of intra-ventrolateral periaqueductal grey (VLPAG) administration of DM2 on formalin-induced nocifensive responses in rats. In

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