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279552

4-Chloro-3-ethylphenol

97%

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About This Item

Linear Formula:
ClC6H3(C2H5)OH
CAS Number:
14143-32-9
Molecular Weight:
156.61
NACRES:
NA.22
PubChem Substance ID:
24856895
UNSPSC Code:
12352100
EC Number:
237-991-6
MDL number:
MFCD00010822
Assay:
97%
Form:
solid
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assay

97%

form

solid

mp

45-50 °C (lit.)

functional group

chloro

SMILES string

CCc1cc(O)ccc1Cl

InChI

1S/C8H9ClO/c1-2-6-5-7(10)3-4-8(6)9/h3-5,10H,2H2,1H3

InChI key

DVKVZPIRWWREJC-UHFFFAOYSA-N

Application

4-Chloro-3-ethylphenol is a ryanodine receptor antagonist and is commonly used as research tool and diagnostic reagent for malignant hyperthermia.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCF0004
MKBW3055V
MKBQ0591V
00220HJ
12713CE

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Francisco H Andrade et al.
Investigative ophthalmology & visual science, 46(12), 4541-4547 (2005-11-24)
The ultrafast extraocular muscles necessitate tight regulation of free cytosolic Ca2+ concentration ([Ca2+]i). Mitochondrial Ca2+ influx may be fast enough for this role. In the present study, three hypotheses were tested: (1) Mitochondrial Ca2+ uptake regulates [Ca2+]i and production of
Bo Zeng et al.
British journal of pharmacology, 171(5), 1250-1259 (2014-03-29)
Depletion of the Ca(2+) store by ryanodine receptor (RyR) agonists induces store-operated Ca(2+) entry (SOCE). 4-Chloro-3-ethylphenol (4-CEP) and 4-chloro-m-cresol (4-CmC) are RyR agonists commonly used as research tools and diagnostic reagents for malignant hyperthermia. Here, we investigated the effects of
A M Low et al.
British journal of pharmacology, 122(3), 504-510 (1997-11-14)
1. Recently, 4-chloro-3-ethyl phenol (CEP) has been shown to cause the release of internally stored Ca2+ apparently through ryanodine-sensitive Ca2+ channels, in fractionated skeletal muscle terminal cisternae and in a variety of non-excitable cell types. Its action on smooth muscle
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Global Trade Item Number

SKUGTIN
279552-25G04061832279732