284130
Psoralen
97%
Synonym(s):
6,7-Furanocoumarin, 7H-Furo[3,2-g]benzopyran-7-one, Ficusin, Furo[3,2-g]coumarin
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About This Item
Empirical Formula (Hill Notation):
C11H6O3
CAS Number:
Molecular Weight:
186.16
EC Number:
200-639-7
UNSPSC Code:
85151701
PubChem Substance ID:
Beilstein/REAXYS Number:
152784
MDL number:
InChI key
ZCCUUQDIBDJBTK-UHFFFAOYSA-N
InChI
1S/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H
SMILES string
O=C1Oc2cc3occc3cc2C=C1
assay
97%
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Application
Photochemical reagent for the investigation of nucleic acid structure and function.
Disclaimer
Store in dark!
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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F P Gasparro et al.
Environmental and molecular mutagenesis, 31(2), 105-112 (1998-04-17)
Photochemotherapy employing 8-methoxypsoralen and ultraviolet radiation (PUVA) is widely used in the treatment of psoriasis. The photoactivation of psoralens in skin cells leads to DNA photoadduct formation which may be responsible for the efficacy of PUVA. Subsequent mutations may lead
Takuya Furuhashi et al.
PloS one, 8(1), e54895-e54895 (2013-02-01)
Photo(chemo)therapy is widely used to treat psoriasis, the pathogenesis of which might be caused by an imbalance of Th17 cells/regulatory T cells (Treg). In the present study, we evaluated the effects of photo(chemo)therapy on the Th17/Treg balance and Treg function.
Karen S McGinnis et al.
Archives of dermatology, 139(6), 771-775 (2003-06-18)
Multimodality biological response-modifier therapy that includes photopheresis, interferon, and bexarotene is the standard of care in our institution for advanced cutaneous T-cell lymphoma with peripheral blood involvement. We added psoralen plus long-wave UV-A (PUVA) to this regimen in 5 patients
Rende Xu et al.
Clinical immunology (Orlando, Fla.), 142(2), 209-217 (2011-12-16)
Modulation of CD4(+)CD28null T cells through K+ channels could provide potential novel targets for the treatment acute coronary syndrome (ACS). However, the surface phenotype and K+ channel expression of CD4(+)CD28null T cells in patients with ACS is unclear. The aim
Biochemical aspects of psoralen photochemotherapy.
A C Moor et al.
Clinics in dermatology, 14(4), 353-365 (1996-07-01)
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