284327
1,6-Dinitropyrene
98%
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About This Item
Empirical Formula (Hill Notation):
C16H8N2O4
CAS Number:
Molecular Weight:
292.25
UNSPSC Code:
12352100
PubChem Substance ID:
MDL number:
InChI
1S/C16H8N2O4/c19-17(20)13-8-4-10-2-6-12-14(18(21)22)7-3-9-1-5-11(13)16(10)15(9)12/h1-8H
SMILES string
[O-][N+](=O)c1ccc2ccc3c(ccc4ccc1c2c34)[N+]([O-])=O
InChI key
GUXACCKTQWVTLG-UHFFFAOYSA-N
assay
98%
mp
>300 °C (lit.)
General description
1,6-Dinitropyrene is a potent mutagenic components of diesel exhaust and air pollutant. 1,6-Dinitropyrene is an extremely potent genotoxicant in metabolically competent primary cultures of human and rat hepatocytes.
signalword
Danger
hcodes
Hazard Classifications
Carc. 1B
Storage Class
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Regulatory Information
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B E Butterworth et al.
Mutation research, 122(1), 73-80 (1983-10-01)
1,6-Dinitropyrene (DNP) was found to be an extremely potent genotoxicant in metabolically competent primary cultures of human and rat hepatocytes. Dose-dependent increases in DNA repair as measured by unscheduled DNA synthesis (UDS) were observed in the range from 0.05 to
Akiko H Hashimoto et al.
Environmental and molecular mutagenesis, 47(4), 277-283 (2006-02-21)
1,6-Dinitropyrene (1,6-DNP) is a ubiquitous airborne pollutant found in diesel exhaust. In this study, mutagenesis was examined in the lungs of gpt-delta transgenic mice after intratracheal instillation of 0-0.1 mg 1,6-DNP. In addition, the 1,6-DNP-induced gpt mutation spectrum was compared
B A Smith et al.
Mutation research, 379(1), 61-68 (1997-10-23)
Direct pulmonary instillation of 1,6-dinitropyrene (DNP) into male Fischer 344 rats results in a dose-dependent induction of lung tumors and 6-thioguanine-resistant (TGr) T-lymphocytes. The treatment also results in DNP binding to dG in the lung and in T-lymphocytes. In the
H Ohgaki et al.
Cancer letters, 25(3), 239-245 (1985-01-01)
1-Nitropyrene (1-NP), 1,6-dinitropyrene (1,6-DNP) and 1,8-dinitropyrene (1,8-DNP), which are potent mutagenic components of diesel exhaust and air pollutants, were injected subcutaneously into the back of F344 rats. No tumor was induced by experimental day 650 in rats treated with 40
I Tahara et al.
Mutation research, 343(2-3), 109-119 (1995-06-01)
This study examined the stability of mutagenic 1-nitropyrene (1-NP) and (1,6-dinitropyrene (1,6-diNP) in environmental water samples and various soil suspensions containing 0.1% peptone and in water samples containing no peptone. The water samples or the soil suspensions were mixed with
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