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Merck
CN

285269

(+)-Bicuculline

98%

Synonym(s):

Bucuculline

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About This Item

Empirical Formula (Hill Notation):
C20H17NO6
CAS Number:
Molecular Weight:
367.35
PubChem Substance ID:
UNSPSC Code:
12352005
Beilstein/REAXYS Number:
98786
MDL number:
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Product Name

(+)-Bicuculline, 98%

SMILES string

[H][C@]1(OC(=O)c2c3OCOc3ccc12)[C@@]4([H])N(C)CCc5cc6OCOc6cc45

InChI

1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1

InChI key

IYGYMKDQCDOMRE-ZWKOTPCHSA-N

assay

98%

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Biochem/physiol Actions

(+)-Bicuculline is a GABAA receptor antagonist.

Regulatory Information

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G Palazzolo et al.
Scientific reports, 7(1), 8499-8499 (2017-08-19)
The need for in vitro models that mimic the human brain to replace animal testing and allow high-throughput screening has driven scientists to develop new tools that reproduce tissue-like features on a chip. Three-dimensional (3D) in vitro cultures are emerging
Ning Gu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(19), 8276-8287 (2013-05-10)
Increasing evidence suggests that synchronization between brain regions is essential for information exchange and memory processes. However, it remains incompletely known which synaptic mechanisms contribute to the process of synchronization. Here, we investigated whether NMDA receptor-mediated synaptic plasticity was an
Giuseppina Martella et al.
Brain : a journal of neurology, 132(Pt 9), 2336-2349 (2009-07-31)
DYT1 dystonia is a severe form of inherited dystonia, characterized by involuntary twisting movements and abnormal postures. It is linked to a deletion in the dyt1 gene, resulting in a mutated form of the protein torsinA. The penetrance for dystonia
Yu-Cheng Ho et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(18), 7825-7836 (2013-05-03)
Neuropathic pain, a chronic pain due to neuronal lesion, remains unaltered even after the injury-induced spinal afferent discharges have declined, suggesting an involvement of supraspinal dysfunction. The midbrain ventrolateral periaqueductal gray (vlPAG) is known to be a crucial supraspinal region

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