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285838

Ethopropazine hydrochloride

Name: Ethopropazine hydrochloride
Brand: ALDRICH

98%

Synonym(s):

10-(2-Diethylaminopropyl)phenothiazine, 10-[2-(Diethylamino)propyl]phenothiazine hydrochloride, Dibutil hydrochloride, Parkin

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₄N₂S · HCl

CAS Number:

1094-08-2

Molecular Weight:

348.93

EC Number:

214-134-4

UNSPSC Code:

12352103

MDL number:

MFCD00012653

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Properties

assay

98%

SMILES string

Cl[H].CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13

InChI

1S/C19H24N2S.ClH/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21;/h6-13,15H,4-5,14H2,1-3H3;1H

InChI key

VXPCQISYVPFYRK-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Ethoproprazine hydrochloride is an inhibitor of butyrylcholinesterase; antiparkinsonian

Ethoproprazine hydrochloride is an inhibitor of butyrylcholinesterase; antiparkinsonian. It reduces extrapyramidal motor effects, characteristic of Parkinson′s disease; also alleviates thermal hyperalgesia in rats.

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Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors--analogues of SAD-128.

Kamil Musilek et al.

Bioorganic & medicinal chemistry letters, 21(1), 150-154 (2010-12-15)

Carbamate inhibitors (e.g., pyridostimine bromide) are used as a pre-exposure treatment for the prevention of organophosphorus poisoning. They work by blocking acetylcholinesterase's (AChE) native function and thus protect AChE against irreversible inhibition by organophosphorus compounds. However, carbamate inhibitors are known

Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment.

Kamil Musilek et al.

European journal of medicinal chemistry, 46(2), 811-818 (2011-01-18)

Inhibitors of acetylcholinesterase are compounds widely used in the treatment of various diseases, such as Alzheimer's disease, glaucoma and Myasthenia gravis (MG). Compounds used in the therapy of MG posses a positive charge in the molecule to ensure peripheral effect

Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment.

Marketa Komloova et al.

Bioorganic & medicinal chemistry letters, 21(8), 2505-2509 (2011-03-15)

This paper describes the preparation and in vitro evaluation of 18 newly prepared bis-quinolinium inhibitors on human recombinant acetylcholinesterase (AChE) and human plasmatic butyrylcholinesterase (BChE). Their inhibitory (IC(50)) and was compared to the chosen standards ambenonium dichloride, edrophonium chloride, BW284c51