286567
Mephenesin
98%
Synonym(s):
3-(2-Methylphenoxy)-1,2-propanediol
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About This Item
Linear Formula:
CH3C6H4OCH2CH(OH)CH2OH
CAS Number:
Molecular Weight:
182.22
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
200-427-4
MDL number:
Assay:
98%
Form:
powder
InChI key
JWDYCNIAQWPBHD-UHFFFAOYSA-N
InChI
1S/C10H14O3/c1-8-4-2-3-5-10(8)13-7-9(12)6-11/h2-5,9,11-12H,6-7H2,1H3
SMILES string
Cc1ccccc1OCC(O)CO
assay
98%
form
powder
bp
153-154 °C/4 mmHg (lit.)
mp
69-71 °C (lit.)
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Jing Quan et al.
Bioorganic & medicinal chemistry, 15(4), 1741-1748 (2006-12-21)
A facile, high regioselective enzymatic synthesis approach for the preparation of amphipathic prodrugs with saccharides of mephenesin and chlorphenesin was developed. Firstly, transesterification of two drugs with divinyl dicarboxylates with different carbon chain length was performed under the catalysis of
K Sakitama et al.
Japanese journal of pharmacology, 60(2), 127-131 (1992-10-01)
The effects of morphine-HCl and mephenesin on the flexor reflex mediated by group II afferent fibers were investigated. The flexor reflex was recorded by means of the electromyogram (EMG) evoked in the muscle tibialis anterior by stimulation of the ipsilateral
A Y Junnarkar et al.
Pharmacological research, 26(2), 131-141 (1992-09-01)
The neuropsychopharmacological profile of a new centrally acting skeletal muscle relaxant, 2,4-dihydro[1,2,4]triazolo[3,4-c][1,4]benzothiazine-1-one (IDPH-791), an analogue of triazolobenzothiazine, has been described and compared to mephenesin, a well known centrally-acting muscle relaxant. IDPH-791 was found to be safer and of longer duration
A Schulze-Dirks et al.
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 44(6), 403-406 (1993-06-01)
A case of erythema multiforme-like allergic contact dermatitis due to midysalb, an ointment containing mephenesine is described. Patch testing showed marked sensitization to mephenesine, with positive reactions to different dilutions down to 0.1%. It is unlikely that the weak reaction
Nedim Kasumacic et al.
The Journal of physiology, 588(Pt 24), 4905-4925 (2010-10-22)
Proper control of movement and posture occurs partly via descending projections from the vestibular nuclei to spinal motor circuits. Days before birth in rodents, vestibulospinal neurons develop axonal projections that extend to the spinal cord. How functional these projections are
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