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286656

α-Methyl-DL-phenylalanine

Name: α-Methyl-<SC>DL</SC>-phenylalanine
Brand: ALDRICH

98%

Synonym(s):

(±)-2-Amino-2-methyl-3-phenylpropionic acid

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About This Item

Linear Formula:

C₆H₅CH₂C(CH₃)(NH₂)CO₂H

CAS Number:

1132-26-9

Molecular Weight:

179.22

UNSPSC Code:

12352209

NACRES:

NA.22

PubChem Substance ID:

24857247

MDL number:

MFCD00010512

Beilstein/REAXYS Number:

2803960

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Properties

Quality Level

100

assay

98%

reaction suitability

reaction type: solution phase peptide synthesis

mp

293-294 °C (dec.) (lit.)

application(s)

peptide synthesis

SMILES string

CC(N)(Cc1ccccc1)C(O)=O

InChI

1S/C10H13NO2/c1-10(11,9(12)13)7-8-5-3-2-4-6-8/h2-6H,7,11H2,1H3,(H,12,13)

InChI key

HYOWVAAEQCNGLE-UHFFFAOYSA-N

Description

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing alpha-methylphenylalanyl based phosphotyrosyl mimetics.

Shinya Oishi et al.

Journal of medicinal chemistry, 48(3), 764-772 (2005-02-04)

Previous work has shown that incorporation of either 1-aminocyclohexanecarboxylic acid (Ac6c) or alpha-methyl-p-phosphonophenylalanine ((alpha-Me)Ppp) in the phosphotyrosyl (pTyr) C-proximal position (pY + 1 residue) of Grb2 SH2 domain binding peptides confers high affinity. The tetralin-based (S)-2-amino-6-phosphonotetralin-2-carboxylic acid (Atc(6-PO3H2)) simultaneously presents

Developmental changes of cerebral phenylalanine uptake from severely elevated blood levels.

O Greengard et al.

Neurochemical research, 9(6), 837-848 (1984-06-01)

Brain phenylalanine concentrations at plasma levels raised to that in phenylketonuric subjects were studied in rats from fetal through postnatal life. Suppression of the hepatic phenylalanine hydroxylase with alpha methylphenylalanine, and injections of age-adjusted doses of phenylalanine on the next

Modulation of cerebral catecholamine concentrations during hyperphenylalaninaemia.

C A Brass et al.

The Biochemical journal, 208(3), 765-771 (1982-12-15)

Hyperphenylalaninaemia induced by daily injections of alpha-methylphenylalanine plus phenylalanine caused 20-40% decreases in cerebral dopamine (3,4-dihydroxyphenethylamine) and noradrenaline in 7- and 11-day-old rats. alpha-Methylphenylalanine alone as well as phenylalanine alone caused cerebral dopamine depletion. However, the effects were not additive

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Global Trade Item Number

SKU	GTIN
286656-1G	04061826264799