288489
1,3-Dibenzyloxy-2-propanol
97%
Synonym(s):
1,3-Bis(benzyloxy)-2-propanol, 1,3-Di-O-benzylglycerol
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About This Item
Linear Formula:
(C6H5CH2OCH2)2CHOH
CAS Number:
Molecular Weight:
272.34
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1986774
Assay:
97%
Form:
liquid
InChI
1S/C17H20O3/c18-17(13-19-11-15-7-3-1-4-8-15)14-20-12-16-9-5-2-6-10-16/h1-10,17-18H,11-14H2
SMILES string
OC(COCc1ccccc1)COCc2ccccc2
InChI key
ARLSYSVVBAMYKA-UHFFFAOYSA-N
assay
97%
form
liquid
bp
226-227 °C/3 mmHg (lit.)
density
1.103 g/mL at 20 °C (lit.)
functional group
ether, hydroxyl, phenyl
Application
1,3-Dibenzyloxy-2-propanol was used in the synthesis of 1,3-dibenzyloxyacetone. It was also used as precursor to antiviral intermediates.
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
230.0 °F - closed cup
flash_point_c
110 °C - closed cup
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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A trihydroxy acyclonucleoside series.
Ogilvie KK, et al.
Canadian Journal of Chemistry, 62 (8), 1622-1627 (1984)
J C Martin et al.
Journal of medicinal chemistry, 26(5), 759-761 (1983-05-01)
The synthesis of a new acyclic analogue of deoxyguanosine, 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine (DHPG, 1), is described starting from epichlorohydrin via condensation of 2-O-(acetoxymethyl)-1,3-di-O-benzylglycerol (5) with N2,9-diacetylguanine (6). In vitro studies indicate that DHPG is a potent and broad-acting (herpes simplex virus types
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