291196
Creatine
98%
Synonym(s):
(α-Methylguanido)acetic acid, N-Amidinosarcosine
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About This Item
Linear Formula:
H2NC(=NH)N(CH3)CH2CO2H
CAS Number:
Molecular Weight:
131.13
EC Number:
200-306-6
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
907175
MDL number:
assay
98%
SMILES string
CN(CC(O)=O)C(N)=N
InChI
1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9)
InChI key
CVSVTCORWBXHQV-UHFFFAOYSA-N
Biochem/physiol Actions
Creatine is a nitrogenous compound that acts as a high-energy reservoir for the rapid regeneration of ATP.
Creatine is a nitrogenous compound that acts as a high-energy reservoir for the rapid regeneration of ATP. Approximately 95% of creatine is found in skeletal muscle, primarily as phosphocreatine. Creatine can be acquired through dietary consumption or formed from L-arginine, glycine, and L-methionine in a multi-step reaction that occurs in the kidneys and liver. Creatine is then transported to muscle tissue. Creatine supplementation is used for the enhancement of sports performance, primarily by increasing muscle mass. Creatine is also being investigated as a treatment of neuromuscular diseases, where it may aid in neuroprotection and by improving the cellular bioenergetic state.
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Samit Malhotra et al.
Continuum (Minneapolis, Minn.), 19(1 Sleep Disorders), 67-85 (2013-02-13)
This review discusses the various causes of primary hypersomnias with emphasis on clinical recognition, diagnosis, and treatment options. Narcolepsy is probably the most fascinating syndrome causing excessive daytime sleepiness. With increasing understanding of the hypocretin/orexin pathways and the neurotransmitters that
Creatine--a dispensable metabolite?
Heinrich Taegtmeyer et al.
Circulation research, 112(6), 878-880 (2013-03-16)
Sergej M Ostojic et al.
International journal of medical sciences, 10(2), 141-147 (2013-01-19)
Guanidinoacetic acid (GAA) is a natural precursor of creatine, yet the potential use of GAA as a nutritional additive for restoring creatine availability in humans has been limited by unclear efficacy and safety after exogenous GAA administration. The present study