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Merck
CN

293490

2-Benzylimidazoline

99%

Synonym(s):

2-Benzyl-2-imidazoline, 2-Benzyl-4,5-dihydro-1H-imidazole, Benzidazol, NSC 35110, Phenylmethylimidazoline, Tolazoline

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About This Item

Empirical Formula (Hill Notation):
C10H12N2
CAS Number:
59-98-3
Molecular Weight:
160.22
NACRES:
NA.22
PubChem Substance ID:
24857660
UNSPSC Code:
12352100
EC Number:
200-448-9
MDL number:
MFCD00005182
Assay:
99%

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InChI key

JIVZKJJQOZQXQB-UHFFFAOYSA-N

InChI

1S/C10H12N2/c1-2-4-9(5-3-1)8-10-11-6-7-12-10/h1-5H,6-8H2,(H,11,12)

SMILES string

C1CN=C(Cc2ccccc2)N1

assay

99%

mp

66-69 °C (lit.)

solubility

alcohol: freely soluble, chloroform: soluble, diethyl ether: very slightly soluble, ethyl acetate: very slightly soluble, water: freely soluble

functional group

phenyl

storage temp.

2-8°C

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), HRH1(3269), HRH2(3274), HTR1B(3351), HTR1D(3352)

General description

2-Benzylimidazoline is an active vasodilator.

Application

2-Benzylimidazoline has been used in the preparation of phenyl-2,3-dihydroimidazo[1,2-a]pyridinone derivatives via condensation with of a series of β-keto esters.
Reactant for synthesis of imidazoline-containing drug

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKBZ9773V
MKBL4753V
03515EE
20415TR
11518LY

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Tulio M Prado et al.
Veterinary anaesthesia and analgesia, 35(3), 201-207 (2008-02-20)
To evaluate the anesthetic and cardiorespiratory effects of two doses of intramuscular (IM) xylazine/ketamine in alpacas, and to determine if tolazoline would reduce the anesthetic recovery time. Prospective randomized crossover study. Six castrated male alpacas. Each alpaca received a low
Derivatives of phenyl-2, 3-dihydroimidazo [1, 2-a] pyridinone.
Magatti CV and Villani FJ.
Journal of Heterocyclic Chemistry, 15(6), 1021-1023 (1978)
J A E Hubbell et al.
Equine veterinary journal, 38(3), 238-241 (2006-05-19)
The ability to shorten the duration of sedation would potentially improve safety and utility of detomidine. To determine the effects of tolazoline and atipamezole after detomidine sedation. Administration of tolazoline or atipamezole would not affect detomidine sedation. In a randomised
Beulah Leitch et al.
The Journal of comparative neurology, 462(1), 55-70 (2003-05-23)
The role of the biogenic amine octopamine in modulating cholinergic synaptic transmission between the locust forewing stretch receptor neuron (fSR) and the first basalar motoneuron (BA1) was investigated. The amines 5-hydroxytryptamine (5-HT, serotonin) and dopamine were also studied. Bath application
William R DuBois et al.
Veterinary anaesthesia and analgesia, 31(2), 90-96 (2004-04-01)
To evaluate the anesthetic and cardiorespiratory effects of two doses of intramuscular xylazine/ketamine in llamas, and to determine if an intramuscular injection of tolazoline would shorten the anesthesia recovery time. Prospective randomized study. Six castrated male llamas. Each llama received
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