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Merck
CN

319813

Methyl cyanoformate

99%

Synonym(s):

2-Methoxy-2-oxoacetonitrile, Cyanoformic acid methyl ester, Mander′s reagent, Methyl carbonocyanidate, [(Cyanocarbonyl)oxy]methane

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About This Item

Linear Formula:
NCCO2CH3
CAS Number:
17640-15-2
Molecular Weight:
85.06
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24859191
EC Number:
241-626-6
Beilstein/REAXYS Number:
1742994
MDL number:
MFCD00013420
Assay:
99%
Form:
liquid

Key Documents

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InChI key

OBWFJXLKRAFEDI-UHFFFAOYSA-N

InChI

1S/C3H3NO2/c1-6-3(5)2-4/h1H3

SMILES string

COC(=O)C#N

assay

99%

form

liquid

Quality Level

100

bp

100-101 °C (lit.)

density

1.072 g/mL at 25 °C (lit.)

functional group

ester, nitrile

Related Categories

General description

Methyl cyanoformate is an organic compound that is commonly used as a source of the methoxycarbonyl group in organic synthesis. It is most frequently used as a reagent to synthesize regioselective β-keto esters via C-acylation of lithium enolates. In comparison with more traditional reagents such as acyl halides, anhydrides, and carbon dioxide, it is regarded as a superior acylating agent.

Application

Selective acylating reagent.

pictograms

FlameSkull and crossbones
GHS02,GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

78.8 °F - closed cup

flash_point_c

26 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品
非剧毒-急性毒性1
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Certificates of Analysis (COA)

Lot/Batch Number
BCCL1719
BCCL6844
BCCL0817
STBJ9284
STBJ9348

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Aldrichimica Acta, 20, 53-53 (1987)
D L Selwood et al.
Journal of medicinal chemistry, 36(23), 3503-3510 (1993-11-12)
A variety of isosteres of the DNA polymerase inhibitor aphidicolin were synthesized as potential antiherpes agents. Modeling studies indicated that the bicyclooctane C, D rings of aphidicolin could be replaced by an aromatic moiety while maintaining the spatial arrangement of
Tetrahedron, 48, 7979-7979 (1992)
Tetrahedron Letters, 34, 8553-8553 (1993)

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