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324833

2-Bromo-5-nitropyridine

Name: 2-Bromo-5-nitropyridine
Brand: ALDRICH

99%

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About This Item

Empirical Formula (Hill Notation):

C₅H₃BrN₂O₂

CAS Number:

4487-59-6

Molecular Weight:

202.99

NACRES:

NA.22

PubChem Substance ID:

24859471

UNSPSC Code:

12352100

EC Number:

224-777-2

MDL number:

MFCD00006222

Assay:

99%

Form:

solid

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Properties

assay

99%

form

solid

bp

145-147 °C/10 mmHg (lit.)

mp

139-141 °C (lit.)

functional group

bromo, nitro

SMILES string

[O-][N+](=O)c1ccc(Br)nc1

InChI

1S/C5H3BrN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H

InChI key

HUUFTVUBFFESEN-UHFFFAOYSA-N

Description

Application

2-Bromo-5-nitropyridine was used in preparation of boc-protected (piperazin-1-ylmethyl)biaryls via microwave-mediated Suzuki-Miyaura coupling with (boc-piperazin-1-ylmethyl)phenylboronic acid pinacol esters. It was also used in the synthesis of 2-pyridyl analogs.

pictograms

GHS06

signalword

Danger

hcodes

H301,H315,H319,H335

pcodes

P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

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Exploration of pyridine containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors.

Hashim Motiwala et al.

Bioorganic & medicinal chemistry letters, 21(19), 5812-5817 (2011-08-27)

The diacylglycerol acyltransferase enzyme, DGAT1, presents itself as a potential target for obesity as this enzyme is dedicated to the final committed step in triglyceride biosynthesis. Biphenyl ureas, exemplified by compound 4, have been reported to be potent hDGAT1 inhibitors.

Synthesis of a (piperazin-1-ylmethyl) biaryl library via microwave-mediated Suzuki-Miyaura cross-couplings.

Spencer J, et al.

Tetrahedron Letters, 52(31), 3963-3968 (2011)

Global Trade Item Number

SKU	GTIN
324833-5G	04061826711828
324833-1G	04061825753249