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Merck
CN

328898

9-Fluoreneacetic acid

99%

Synonym(s):

9-Fluorenylacetic acid

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About This Item

Empirical Formula (Hill Notation):
C15H12O2
CAS Number:
Molecular Weight:
224.25
PubChem Substance ID:
UNSPSC Code:
12352100
Beilstein/REAXYS Number:
1969039
MDL number:
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SMILES string

OC(=O)CC1c2ccccc2-c3ccccc13

InChI

1S/C15H12O2/c16-15(17)9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14H,9H2,(H,16,17)

InChI key

WFSMJMTYIMFHPV-UHFFFAOYSA-N

assay

99%

mp

133-135 °C (lit.)

Gene Information

rat ... Akr1b1(24192)

Application

9-Fluoreneacetic acid was used in preparation of pyrokinin class of insect neuropeptides. It was also used in preparation of N-(9-fluoreneacetyl)-L-leucine.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Y S Lee et al.
Bioorganic & medicinal chemistry, 6(10), 1811-1819 (1998-12-05)
Molecular modeling studies using the CHARMM method have been conducted to study the binding modes of aldose reductase inhibitors at the active site of aldose reductase. The energy minimized structures of aldose reductase with six structurally diverse inhibitors (spirofluorene-9,5'-imidazolidine-2',4'-dione (1)
P E Teal et al.
Regulatory peptides, 72(2-3), 161-167 (1998-07-04)
Amphiphilic pseudopeptide analogs of Phe-Thr-Pro-Arg-Leu-NH2, representing the active C-terminal core pentapeptide of the pyrokinin class of insect neuropeptides, were synthesized by replacement of phenylalanine with hydrocinnamic acid (Hca-Thr-Pro-Arg-Leu-NH2), or addition of 1-pyrenebutyric acid (Pba-Phe-Thr-Pro-Arg-Leu-NH2) or 9-fluoreneacetic acid (Fla-Phe-Thr-Pro-Arg-Leu-NH2). The pseudopeptides
H M Zhang et al.
Journal of pharmaceutical and biomedical analysis, 10(8), 577-586 (1992-08-01)
Two silica reagents based on a 4-hydroxy-3-nitrobenzoyl backbone were synthesized and characterized with 9-fluorenylmethoxycarbonyl (FMOC) and 9-fluoreneacetyl (FA) tags. These reagents were tested by derivatization of primary and secondary amines. Derivatization conditions such as temperature, time and triethylamine catalyst were
Isaac O Donkor et al.
Journal of medicinal chemistry, 51(14), 4346-4350 (2008-07-19)
A series of peptidyl alpha-ketoacids and alpha-ketoesters was synthesized and studied as mu-calpain inhibitors. Docking studies revealed that the mu-calpain inhibitory activity of the compounds is influenced by hydrogen bonding interactions and the potential for ionic interaction with active site
A J Bourque et al.
Biomedical chromatography : BMC, 8(2), 53-62 (1994-03-01)
An automated system is described for the simultaneous extraction and derivatization of nucleophilic compounds from various biological media. The method includes the use of a solid-phase reagent containing a 9-fluorenylacetate activated ester. The reagent is based on a controlled pore

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