Key Documents

View All Documentation

331902

5′-Deoxythymidine

Name: 5′-Deoxythymidine
Brand: ALDRICH

98%

Synonym(s):

2′,5′-Dideoxythymidine

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₄N₂O₄

CAS Number:

3458-14-8

Molecular Weight:

226.23

UNSPSC Code:

12352100

PubChem Substance ID:

24860008

MDL number:

MFCD00057398

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

assay

98%

optical activity

[α]28/D +8.9°, c = 0.6 in H₂O

mp

192-193 °C (lit.)

SMILES string

C[C@H]1O[C@H](C[C@@H]1O)N2C=C(C)C(=O)NC2=O

InChI

1S/C10H14N2O4/c1-5-4-12(10(15)11-9(5)14)8-3-7(13)6(2)16-8/h4,6-8,13H,3H2,1-2H3,(H,11,14,15)/t6-,7+,8-/m1/s1

InChI key

UGUILUGCFSCUKR-GJMOJQLCSA-N

Description

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

新产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

07714MT

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Membrane permeation characteristics of 5'-modified thymidine analogs.

B A Domin et al.

Molecular pharmacology, 41(5), 950-956 (1992-05-01)

The membrane permeation characteristics of 5'-deoxythymidine (5'-ddThd) and 5'-azido-5'-deoxythymidine (5'-N3-5'-ddThd) were investigated in human erythrocytes, with an inhibitor-stop assay, at 20 degrees. Uptake of both nucleoside analogs occurred without metabolism, was nonconcentrative, and was partially inhibited by nucleosides or inhibitors

Formation of aminyl radicals on electron attachment to AZT: abstraction from the sugar phosphate backbone versus one-electron oxidation of guanine.

Amitava Adhikary et al.

The journal of physical chemistry. B, 114(28), 9289-9299 (2010-06-26)

Employing electron spin resonance (ESR) spectroscopy, we have characterized the radicals formed in 3'-azido-3'-deoxythymidine (3'-AZT) and in its 5'-analog 5'-azido-5'-deoxythymidine (5'-AZT) after electron attachment in gamma-irradiated aqueous (H(2)O or D(2)O) glassy (7.5 M LiCl) systems. ESR spectral studies and theoretical

Synthesis and HIV-1 reverse transcriptase inhibitor activity of some 2,5,6-substituted benzoxazole, benzimidazole, benzothiazole and oxazolo(4,5-b)pyridine derivatives.

Ayşegül Akbay et al.

Arzneimittel-Forschung, 53(4), 266-271 (2003-06-06)

In this study, the synthesis of some benzoxazoles and their analogues were described and their antiviral activities were studied together with the previously synthesized 2,5,6-trisubstituted benzoxazole, benzothiazole, benzimidazole and oxazolo(4,5-b)pyridine derivatives. The reverse transcriptase (RT) inhibitory activity of these compounds

View All Related Papers