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333328

6-Ethoxy-2-benzothiazolesulfonamide

Name: 6-Ethoxy-2-benzothiazolesulfonamide
Brand: ALDRICH

97%

Synonym(s):

6-Ethoxyzolamide, Ethoxzolamide

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₀N₂O₃S₂

CAS Number:

452-35-7

Molecular Weight:

258.32

NACRES:

NA.22

PubChem Substance ID:

24860121

UNSPSC Code:

12352100

EC Number:

207-199-5

MDL number:

MFCD00057089

Assay:

97%

Form:

solid

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Properties

assay

97%

form

solid

mp

190-193 °C (lit.)

SMILES string

CCOc1ccc2nc(sc2c1)S(N)(=O)=O

InChI

1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)

InChI key

OUZWUKMCLIBBOG-UHFFFAOYSA-N

Gene Information

human ... CA1(759), CA12(771), CA13(377677), CA14(23632), CA2(760), CA3(761), CA4(762), CA5A(763), CA5B(11238), CA6(765), CA7(766), CA9(768)
mouse ... Car5a(12352)

Description

General description

6-Ethoxy-2-benzothiazolesulfonamide is a membrane permeable carbonic anhydrase inhibitor and its ocular disposition and pharmacology in normal albino rabbits has been investigated. It causes inhibition of insulin degradation in vitro.

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Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Carbonic anhydrase II increases the activity of the human electrogenic Na+/HCO3- cotransporter.

Holger M Becker et al.

The Journal of biological chemistry, 282(18), 13508-13521 (2007-03-14)

Several acid/base-coupled membrane transporters, such as the electrogenic sodium-bicarbonate cotransporter (NBCe1), have been shown to bind to different carbonic anhydrase isoforms to create a "transport metabolon." We have expressed NBCe1 derived from human kidney in oocytes of Xenopus leavis and

Studies of the effect of carbutamide on glucose-6-phosphatase.

C A KUETHER et al.

Diabetes, 6(1), 23-25 (1957-01-01)

Optimization of Acetazolamide-Based Scaffold as Potent Inhibitors of Vancomycin-Resistant Enterococcus.

Jatinder Kaur et al.

Journal of medicinal chemistry, 63(17), 9540-9562 (2020-08-14)

Vancomycin-resistant enterococci (VRE) are the second leading cause of hospital-acquired infections (HAIs) attributed to a drug-resistant bacterium in the United States, and resistance to the frontline treatments is well documented. To combat VRE, we have repurposed the FDA-approved carbonic anhydrase

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Global Trade Item Number

SKU	GTIN
333328-1G	04061826732434