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Merck
CN

333328

Sigma-Aldrich

6-Ethoxy-2-benzothiazolesulfonamide

97%

Synonym(s):

6-Ethoxyzolamide, Ethoxzolamide

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About This Item

Empirical Formula (Hill Notation):
C9H10N2O3S2
CAS Number:
452-35-7
Molecular Weight:
258.32
EC Number:
207-199-5
MDL number:
MFCD00057089
UNSPSC Code:
12352100
PubChem Substance ID:
24860121
NACRES:
NA.22

Key Documents

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Assay

97%

form

solid

mp

190-193 °C (lit.)

SMILES string

CCOc1ccc2nc(sc2c1)S(N)(=O)=O

InChI

1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)

InChI key

OUZWUKMCLIBBOG-UHFFFAOYSA-N

Gene Information

human ... CA1(759), CA12(771), CA13(377677), CA14(23632), CA2(760), CA3(761), CA4(762), CA5A(763), CA5B(11238), CA6(765), CA7(766), CA9(768)
mouse ... Car5a(12352)

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General description

6-Ethoxy-2-benzothiazolesulfonamide is a membrane permeable carbonic anhydrase inhibitor and its ocular disposition and pharmacology in normal albino rabbits has been investigated. It causes inhibition of insulin degradation in vitro.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCG0797
MKBL4148V
76896KJV
76896KJ
08305MH

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Basel H Abuaita et al.
Infection and immunity, 77(9), 4111-4120 (2009-07-01)
Vibrio cholerae is a gram-negative bacterium that is the causative agent of cholera, a severe diarrheal illness. The two biotypes of V. cholerae O1 capable of causing cholera, classical and El Tor, require different in vitro growth conditions for induction
Xenia Filip et al.
Physical chemistry chemical physics : PCCP, 13(40), 17978-17986 (2011-09-21)
A solid state structural investigation of ethoxzolamide is performed on microcrystalline powder by using a multi-technique approach that combines X-ray powder diffraction (XRPD) data analysis based on direct space methods with information from (13)C((15)N) solid-state Nuclear Magnetic Resonance (SS-NMR) and
Eric T Mack et al.
Journal of the American Chemical Society, 134(1), 333-345 (2011-11-18)
This paper describes a synthetic dimer of carbonic anhydrase, and a series of bivalent sulfonamide ligands with different lengths (25 to 69 Å between the ends of the fully extended ligands), as a model system to use in examining the
Kerry L Peña et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(6), 2455-2460 (2010-02-06)
Cyanobacterial RuBisCO is sequestered in large, icosahedral, protein-bounded microcompartments called carboxysomes. Bicarbonate is pumped into the cytosol, diffuses into the carboxysome through small pores in its shell, and is then converted to CO(2) by carbonic anhydrase (CA) prior to fixation.
Andreza Ribeiro et al.
Journal of the Royal Society, Interface, 9(74), 2059-2069 (2012-04-12)
Polymeric micelles of single and mixed poloxamines (Tetronic) were evaluated regarding their ability to host the antiglaucoma agent ethoxzolamide (ETOX) for topical ocular application. Three highly hydrophilic varieties of poloxamine (T908, T1107 and T1307) and a medium hydrophilic variety (T904)
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