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Merck
CN

333328

6-Ethoxy-2-benzothiazolesulfonamide

97%

Synonym(s):

6-Ethoxyzolamide, Ethoxzolamide

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About This Item

Empirical Formula (Hill Notation):
C9H10N2O3S2
CAS Number:
452-35-7
Molecular Weight:
258.32
NACRES:
NA.22
PubChem Substance ID:
24860121
UNSPSC Code:
12352100
EC Number:
207-199-5
MDL number:
MFCD00057089
Assay:
97%
Form:
solid

Key Documents

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InChI key

OUZWUKMCLIBBOG-UHFFFAOYSA-N

InChI

1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)

SMILES string

CCOc1ccc2nc(sc2c1)S(N)(=O)=O

assay

97%

form

solid

mp

190-193 °C (lit.)

Gene Information

human ... CA1(759), CA12(771), CA13(377677), CA14(23632), CA2(760), CA3(761), CA4(762), CA5A(763), CA5B(11238), CA6(765), CA7(766), CA9(768)
mouse ... Car5a(12352)

General description

6-Ethoxy-2-benzothiazolesulfonamide is a membrane permeable carbonic anhydrase inhibitor and its ocular disposition and pharmacology in normal albino rabbits has been investigated. It causes inhibition of insulin degradation in vitro.

signalword

Warning

pictograms

Exclamation mark
GHS07

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCG0797
MKBL4148V
76896KJV
76896KJ
08305MH

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Andreza Ribeiro et al.
Journal of the Royal Society, Interface, 9(74), 2059-2069 (2012-04-12)
Polymeric micelles of single and mixed poloxamines (Tetronic) were evaluated regarding their ability to host the antiglaucoma agent ethoxzolamide (ETOX) for topical ocular application. Three highly hydrophilic varieties of poloxamine (T908, T1107 and T1307) and a medium hydrophilic variety (T904)
Basel H Abuaita et al.
Infection and immunity, 77(9), 4111-4120 (2009-07-01)
Vibrio cholerae is a gram-negative bacterium that is the causative agent of cholera, a severe diarrheal illness. The two biotypes of V. cholerae O1 capable of causing cholera, classical and El Tor, require different in vitro growth conditions for induction
Larissa A Shimoda et al.
American journal of physiology. Lung cellular and molecular physiology, 292(4), L1002-L1012 (2007-01-09)
Hypoxic pulmonary vasoconstriction (HPV) occurs with ascent to high altitude and can contribute to development of high altitude pulmonary edema (HAPE). Vascular smooth muscle contains carbonic anhydrase (CA), and acetazolamide (AZ), a CA inhibitor, blunts HPV and might be useful
T H Maren et al.
Experimental eye research, 55(1), 73-79 (1992-07-01)
We have measured sequentially the concentrations of ethoxzolamide (6-ethoxybenzothiazole-2-sulfonamide) in ocular tissues following its intravenous or topical administration to normal albino rabbits. This was done in parallel with determinations of intraocular pressure (IOP) measured by tonometer or direct manometry. Ethoxzolamide
Matthias C Jecklin et al.
Journal of molecular recognition : JMR, 22(4), 319-329 (2009-04-18)
We performed a systematic comparison of three label-free methods for quantitative assessment of binding strengths of proteins interacting with small molecule ligands. The performance of (1) nanoelectrospray ionization mass spectrometry (nESI-MS), (2) surface plasmon resonance (SPR), and (3) isothermal titration
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