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Merck
CN

333328

6-Ethoxy-2-benzothiazolesulfonamide

97%

Synonym(s):

6-Ethoxyzolamide, Ethoxzolamide

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About This Item

Empirical Formula (Hill Notation):
C9H10N2O3S2
CAS Number:
452-35-7
Molecular Weight:
258.32
NACRES:
NA.22
PubChem Substance ID:
24860121
UNSPSC Code:
12352100
EC Number:
207-199-5
MDL number:
MFCD00057089
Assay:
97%
Form:
solid

Key Documents

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InChI key

OUZWUKMCLIBBOG-UHFFFAOYSA-N

InChI

1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)

SMILES string

CCOc1ccc2nc(sc2c1)S(N)(=O)=O

assay

97%

form

solid

mp

190-193 °C (lit.)

Gene Information

human ... CA1(759), CA12(771), CA13(377677), CA14(23632), CA2(760), CA3(761), CA4(762), CA5A(763), CA5B(11238), CA6(765), CA7(766), CA9(768)
mouse ... Car5a(12352)

General description

6-Ethoxy-2-benzothiazolesulfonamide is a membrane permeable carbonic anhydrase inhibitor and its ocular disposition and pharmacology in normal albino rabbits has been investigated. It causes inhibition of insulin degradation in vitro.

signalword

Warning

pictograms

Exclamation mark
GHS07

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCG0797
MKBL4148V
76896KJV
76896KJ
08305MH

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Studies of the effect of carbutamide on glucose-6-phosphatase.
C A KUETHER et al.
Diabetes, 6(1), 23-25 (1957-01-01)
Jatinder Kaur et al.
Journal of medicinal chemistry, 63(17), 9540-9562 (2020-08-14)
Vancomycin-resistant enterococci (VRE) are the second leading cause of hospital-acquired infections (HAIs) attributed to a drug-resistant bacterium in the United States, and resistance to the frontline treatments is well documented. To combat VRE, we have repurposed the FDA-approved carbonic anhydrase
Holger M Becker et al.
The Journal of biological chemistry, 282(18), 13508-13521 (2007-03-14)
Several acid/base-coupled membrane transporters, such as the electrogenic sodium-bicarbonate cotransporter (NBCe1), have been shown to bind to different carbonic anhydrase isoforms to create a "transport metabolon." We have expressed NBCe1 derived from human kidney in oocytes of Xenopus leavis and
N A Tobey et al.
American journal of physiology. Gastrointestinal and liver physiology, 293(1), G264-G270 (2007-04-14)
The human esophagus is lined by stratified squamous epithelium (ESSE), and in some subjects with reflux disease the distal esophagus becomes lined by Barrett's specialized columnar epithelium (BSCE). ESSE and BSCE differ both histologically and functionally, the latter evident by
Andreza Ribeiro et al.
Journal of the Royal Society, Interface, 9(74), 2059-2069 (2012-04-12)
Polymeric micelles of single and mixed poloxamines (Tetronic) were evaluated regarding their ability to host the antiglaucoma agent ethoxzolamide (ETOX) for topical ocular application. Three highly hydrophilic varieties of poloxamine (T908, T1107 and T1307) and a medium hydrophilic variety (T904)
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