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335673

1-Dodecyl-2-pyrrolidinone

Name: 1-Dodecyl-2-pyrrolidinone
Brand: ALDRICH

99%

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₃₁NO

CAS Number:

2687-96-9

Molecular Weight:

253.42

NACRES:

NA.22

PubChem Substance ID:

24860339

UNSPSC Code:

12352100

EC Number:

403-730-1

MDL number:

MFCD00075066

Assay:

99%

Form:

viscous liquid

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Properties

Quality Level

100

assay

99%

form

viscous liquid

refractive index

n20/D 1.466 (lit.)

bp

202-205 °C/11 mmHg (lit.)

density

0.89 g/mL at 25 °C (lit.)

SMILES string

CCCCCCCCCCCCN1CCCC1=O

InChI

1S/C16H31NO/c1-2-3-4-5-6-7-8-9-10-11-14-17-15-12-13-16(17)18/h2-15H2,1H3

InChI key

NJPQAIBZIHNJDO-UHFFFAOYSA-N

Description

General description

1-Dodecyl-2-pyrrolidinone is an N-alkyl lactam and its reduction with LiH₃BNMe₂ to the corresponding amine has been reported. It is a potential melatonin-specific chemical penetration enhancer.

Application

1-Dodecyl-2-pyrrolidinone was used in the preparation of few-layered flakes of molybdenum disulfide (MoS₂) via liquid phase exfoliation of bulk MoS₂ powder.

pictograms

GHS05,GHS07,GHS09

signalword

Danger

hcodes

H314,H317,H410

pcodes

P261 - P272 - P273 - P280 - P303 + P361 + P353 - P305 + P351 + P338

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 2

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Comparative studies on the anticonvulsant activity of lipophilic derivatives of gamma-aminobutyric acid and 2-pyrrolidinone in mice.

J Nakamura et al.

Journal of pharmacobio-dynamics, 14(1), 1-8 (1991-01-01)

Anticonvulsant activity, degradation into gamma-aminobutyric acid (GABA), and concentration in brain of 1-dodecanoyl-2-pyrrolidinone (I), a lipophilic derivative of a lactam of GABA, were compared with those of N-dodecanoyl GABA (II) and 1-dodecyl-2-pyrrolidinone (III) to get information about their pharmacological mechanisms.

Screening of chemical penetration enhancers for transdermal drug delivery using electrical resistance of skin.

Vijay Krishna Rachakonda et al.

Pharmaceutical research, 25(11), 2697-2704 (2008-08-07)

A novel technique is presented for identifying potential chemical penetration enhancers (CPEs) based on changes in the electrical resistance of skin. Specifically, a multi-well resistance chamber was designed and constructed to facilitate more rapid determination of the effect of CPEs

Enhancing effect of combining two pyrrolidone vehicles on transdermal drug delivery.

H Sasaki et al.

The Journal of pharmacy and pharmacology, 42(3), 196-199 (1990-03-01)

The enhancing effect of combining 1-methyl-2-pyrrolidone (MP) and 1-lauryl-2-pyrrolidone (LP) as the vehicles for transdermal penetration of phenolsulphonphthalein (phenol red) has been investigated by using an in-vitro technique with excised rat skin. LP had a higher enhancing effect on the

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Global Trade Item Number

SKU	GTIN
335673-250ML	04061826740194