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335975

(+)-1-(9-Fluorenyl)ethyl chloroformate solution

18 mM in acetone, derivatization grade (chiral)

Synonym(s):

(+)-FLEC solution

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About This Item

Empirical Formula (Hill Notation):
C16H13ClO2
CAS Number:
107474-79-3
Molecular Weight:
272.73
UNSPSC Code:
12352005
PubChem Substance ID:
24860354
NACRES:
NA.22
MDL number:
MFCD00043429
Form:
liquid
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grade

derivatization grade (chiral)

Quality Level

100

vapor density

2 (vs air)

vapor pressure

180 mmHg ( 20 °C)

form

liquid

concentration

18 mM in acetone

refractive index

n20/D 1.3602

density

0.79 g/mL at 25 °C

functional group

chloro

storage temp.

2-8°C

SMILES string

ClC(=O)OC(C1c2c(cccc2)c3c1cccc3)C

InChI

1S/C16H13ClO2/c1-10(19-16(17)18)15-13-8-4-2-6-11(13)12-7-3-5-9-14(12)15/h2-10,15H,1H3

InChI key

SFRVOKMRHPQYGE-UHFFFAOYSA-N

General description

(+)-1-(9-Fluorenyl)ethyl chloroformate is a highly fluorescent compound1 commonly used as a chiral derivatizing agent for the separation of racemates prior to reversed-phase HPLC analysis.

Application

  • Chiral analysis of β-methylamino alanine (BMAA) enantiomers: Details the use of (+)-1-(9-fluorenyl)-ethyl chloroformate (FLEC) for derivatization followed by LC-MS/MS analysis, improving the understanding of amino acids′ stereochemistry (Zurita et al., 2019).
  • Enantioselective micellar electrokinetic chromatography of dl‐amino acids: Utilizes (+)-1-(9-fluorenyl)ethyl chloroformate derivatization combined with UV-induced fluorescence detection to analyze amino acids, enhancing analytical methodologies (Prior et al., 2018).

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signalword

Danger

Hazard Classifications

Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system

supp_hazards

EUH066

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

1.4 °F

flash_point_c

-17 °C

Regulatory Information

危险化学品
易制毒化学品（3类）

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Certificates of Analysis (COA)

Lot/Batch Number
STBK9257
STBJ7222
STBJ1362
STBD2562V
STBD1747V

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Separation of amino acid enantiomers and chiral amines using precolumn derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate and reversed-phase liquid chromatography.
S Einarsson et al.
Analytical chemistry, 59(8), 1191-1195 (1987-04-15)
Yasushi Hori et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 776(2), 191-198 (2002-07-26)
We have developed a new analytical method to quantify the DL-homoalanine-4-yl(methyl)phosphinate (DL-GLUF) enantiomers in biological specimens using a reversed-phase high-performance liquid chromatography system with a fluorescence detection system. The derivatization of DL-GLUF enantiomers with (+)-1-(9-fluorenyl)ethyl chloroformate was carried out under
Reversed-phase high-performance liquid chromatographic analysis of atenolol enantiomers in plasma after chiral derivatization with (+)-1-(9-fluorenyl) ethyl chloroformate.
Rosseel MT, et al.
Journal of Chromatography. B, Biomedical Applications, 568(1), 239-245 (1991)
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Global Trade Item Number

SKUGTIN
335975-10ML04061837393457
335975-1ML04061837393464