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Merck
CN

338710

(−)-1-(9-Fluorenyl)ethyl chloroformate solution

18 mM in acetone, derivatization grade (chiral)

Synonym(s):

(−)-FLEC

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About This Item

Empirical Formula (Hill Notation):
C16H13ClO2
CAS Number:
154479-90-0
Molecular Weight:
272.73
NACRES:
NA.22
PubChem Substance ID:
24860564
UNSPSC Code:
12352005
MDL number:
MFCD00043429

Key Documents

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Product Name

(−)-1-(9-Fluorenyl)ethyl chloroformate solution, 18 mM in acetone, derivatization grade (chiral)

InChI

1S/C16H13ClO2/c1-10(19-16(17)18)15-13-8-4-2-6-11(13)12-7-3-5-9-14(12)15/h2-10,15H,1H3

SMILES string

CC(OC(Cl)=O)C1c2ccccc2-c3ccccc13

InChI key

SFRVOKMRHPQYGE-UHFFFAOYSA-N

grade

derivatization grade (chiral)

concentration

18 mM in acetone

density

0.79 g/mL at 25 °C

functional group

chloro

storage temp.

2-8°C

Quality Level

100

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General description

(-)-1-(9-Fluorenyl)ethyl chloroformate is mostly used as an in-capillary derivatization agent for the separation of amino acid (AA) derivatives by micellar electrokinetic chromatography (MEKC).

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Central nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

1.4 °F

flash_point_c

-17.0 °C

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

易制毒化学品（3类）
危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
STBJ1138
STBH9667
STBH4960
STBH0350
STBF8436V

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In-capillary derivatization with (-)-1-(9-fluorenyl) ethyl chloroformate as chiral labeling agent for the electrophoretic separation of amino acids.
Fradi I, et al.
Journal of Chromatography A, 1323, 338-347 (2014)
Radu-Cristian Moldovan et al.
Journal of chromatography. A, 1513, 1-17 (2017-08-02)
Over the last 30years, (±)-1-(9-fluorenyl)ethyl chloroformate ((±)-FLEC) was used as a chiral derivatizing agent in various analytical applications involving a wide range of endogenous, pharmaceutical and environmentally relevant molecules. This comprehensive review aims to present all the significant aspects related
Radu-Cristian Moldovan et al.
Journal of chromatography. A, 1564, 199-206 (2018-06-19)
A targeted CE-MS approach was developed for the chiral analysis of biologically relevant amino acids in artificial cerebrospinal fluid (aCSF). In order to achieve chiral resolution, the five amino acids (Ser, Asn, Asp, Gln and Glu) were derivatized with (+)-1-(9-fluorenyl)ethyl
Radu-Cristian Moldovan et al.
Journal of chromatography. A, 1590, 80-87 (2019-01-15)
D-amino acids (AA) analysis is becoming more and more relevant for metabolomics, therefore new analytical tools need to be developed. A common approach to achieve AA enantioseparation is chiral derivatization. Among the chiral derivatization reagents, (+) or (-)-1-(9-fluorenyl) ethyl chloroformate
Radu-Cristian Moldovan et al.
Journal of chromatography. A, 1467, 400-408 (2016-08-25)
In the context of bioanalytical method development, process automatization is nowadays a necessity in order to save time, improve method reliability and reduce costs. For the first time, a fully automatized micellar electrokinetic chromatography-mass spectrometry (MEKC-MS) method with in-capillary derivatization
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