Key Documents

View All Documentation

342157

2-Hydroxy-5-(trifluoromethoxy)benzaldehyde

Name: 2-Hydroxy-5-(trifluoromethoxy)benzaldehyde
Brand: ALDRICH

99%

Synonym(s):

5-(Trifluoromethoxy)salicylaldehyde

Select a Size

Change View

About This Item

Linear Formula:

CF₃OC₆H₃(OH)CHO

CAS Number:

93249-62-8

Molecular Weight:

206.12

NACRES:

NA.22

PubChem Substance ID:

24861033

UNSPSC Code:

12352100

MDL number:

MFCD00075249

Assay:

99%

Form:

solid

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

assay

99%

form

solid

bp

82 °C/60 mmHg (lit.)

mp

31-33 °C (lit.)

SMILES string

Oc1ccc(OC(F)(F)F)cc1C=O

InChI

1S/C8H5F3O3/c9-8(10,11)14-6-1-2-7(13)5(3-6)4-12/h1-4,13H

InChI key

WQUZBERVMUEJTD-UHFFFAOYSA-N

Description

General description

2-Hydroxy-5-(trifluoromethoxy)benzaldehyde is formed as intermediate during the biotransformation pathways of CP-122,721 in humans.

Application

2-Hydroxy-5-(trifluoromethoxy)benzaldehyde may be used in the preparation of :

2-[(E)-2-hydroxy-5-(trifluoromethoxy)benzylideneamino]-4-methylphenol
(E)-2-((3-fluorophenylimino)methyl)-4-(trifluoromethoxy) phenol
2-[(E)-(naphthalen-2-ylimino) methyl]-4-(trifluoromethoxy) phenol

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

(E)-2-[(3-Fluoro-phen-yl)imino-meth-yl]-4-(trifluoro-meth-oxy)phenol.

Yelda Bingöl Alpaslan et al.

Acta crystallographica. Section E, Structure reports online, 66(Pt 3), o510-o510 (2010-01-01)

The title compound, C(14)H(9)F(4)NO(2), is a Schiff base which adopts the phenol-imine tautomeric form in the solid state. The H atom is located on the hydr-oxy O atom rather than on the N atom. This H atom is involved in

Metabolism, pharmacokinetics, and excretion of the substance P receptor antagonist CP-122,721 in humans: structural characterization of the novel major circulating metabolite 5-trifluoromethoxy salicylic acid by high-performance liquid chromatography-tandem mass spectrometry and NMR spectroscopy.

Kevin Colizza et al.

Drug metabolism and disposition: the biological fate of chemicals, 35(6), 884-897 (2007-03-16)

The metabolism, pharmacokinetics, and excretion of a potent and selective substance P receptor antagonist, CP-122,721 [(+)-(2S,3S)-3-(2-methoxy-5-trifluoromethoxybenzylamino)-2-phenylpiperidine], have been studied in six healthy male human subjects [four extensive metabolizers (EMs) and two poor metabolizers (PMs) of CYP2D6) following oral administration of

2-[(E)-(Naphthalen-2-ylimino) methyl]-4-(trifluoromethoxy) phenol.

Pekdemir M, et al.

Acta Crystallographica Section E, Structure Reports Online, 68(4), o10204-o10204 (2012)

View All Related Papers

Global Trade Item Number

SKU	GTIN
342157-500MG	04061826756379