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344648

Triethylamine trihydrofluoride

97%

Synonym(s):

Hydrogen fluoride triethylamine, TREAT-HF

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About This Item

Linear Formula:
(C2H5)3N · 3HF
CAS Number:
73602-61-6
Molecular Weight:
161.21
UNSPSC Code:
12352101
NACRES:
NA.22
PubChem Substance ID:
24861270
EC Number:
277-550-5
Beilstein/REAXYS Number:
5522945
MDL number:
MFCD00043294
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Quality Level

300

assay

97%

refractive index

n20/D 1.3915 (lit.)

bp

70 °C/15 mmHg (lit.)

density

0.989 g/mL at 25 °C (lit.)

functional group

amine

SMILES string

F[H].F[H].F[H].CCN(CC)CC

InChI

1S/C6H15N.3FH/c1-4-7(5-2)6-3;;;/h4-6H2,1-3H3;3*1H

InChI key

IKGLACJFEHSFNN-UHFFFAOYSA-N

General description

Triethylamine trihydrofluoride (TREAT-HF) is a mild and selective reagent for the fluorination of a wide variety of compounds.

Application

TREAT-HF can be used in the synthesis of:
  • Vicinal difluorides from epoxides.
  • 3-fluoroazetidines.
  • 9-(2,3-dideoxy-2-fluoro-β-d-threo-pentofuranosyl)adenine (FddA).
  • Multivicinal hexafluoroalkanes.
  • Aminomethylated 4-fluoropiperidines and 3-fluoropyrrolidines.

Mild and selective reagent that has been used in the fluorination of a wide variety of compounds. For a review, see Aldrichimica Acta.

pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Dam. 1 - Skin Corr. 1A

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

190.4 °F - closed cup

flash_point_c

88 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
SHBT3123
SHBS4321
SHBS3626
SHBP0256
SHBM8698

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Anders Foller Füchtbauer et al.
Scientific reports, 7(1), 2393-2393 (2017-05-26)
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Global Trade Item Number

SKUGTIN
344648-5G04061826758892
344648-100G04061826758823
344648-25G04061826758861
344648-500G04061826758878
344648-1KG04061826758847