346330
trans-3-Bromo-N-ethylcinnamamide
99%
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About This Item
Linear Formula:
BrC6H4CH=CHCONHC2H5
CAS Number:
Molecular Weight:
254.12
UNSPSC Code:
12352100
PubChem Substance ID:
MDL number:
assay
99%
InChI
1S/C11H12BrNO/c1-2-13-11(14)7-6-9-4-3-5-10(12)8-9/h3-8H,2H2,1H3,(H,13,14)/b7-6+
SMILES string
CCNC(=O)\C=C\c1cccc(Br)c1
InChI key
LDCXGZCEMNMWIL-VOTSOKGWSA-N
mp
89-91 °C (lit.)
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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H M Corwin et al.
Epilepsia, 24(4), 427-430 (1983-08-01)
Cinromide (BW-122U) was evaluated in an open pilot study of absence seizures in three naive (previously untreated for absence seizures) patients (one male and two females, 7 to 8 years of age). In these naive patients, cinromide was found to
Cinromide (3-bromo-N-ethylcinnanamide), novel anticonvulsant agent.
F E Soroko et al.
The Journal of pharmacy and pharmacology, 33(11), 741-743 (1981-11-01)
J W Allen et al.
Epilepsia, 24(4), 422-426 (1983-08-01)
A double-blind controlled trial of cinromide in 25 adult subjects with refractory epilepsy using the maximum tolerated dose showed that it possessed no significant antiepileptic properties.
J S Lockard et al.
Epilepsia, 21(2), 177-182 (1980-04-01)
In a previous study (Lockard et al., 1979) Cinromide (3 bromo-N-ethylcinnamamide), an experimental anticonvulsant (Burroughs-Wellcome Pharmaceutical Co.), was given a preliminary evaluation. Since that research was concerned primarily with EEG paroxysms, the present study was conducted to address drug efficacy
E A Lane et al.
Journal of pharmacokinetics and biopharmaceutics, 13(4), 373-386 (1985-08-01)
A previous study of the metabolic fate of cinromide (3-bromo-N-ethylcinnamamide) in rhesus monkey established that half of a dose is metabolized by N-deethylation to an active metabolite, 3-bromocinnamamide. Both cinromide and its proximal metabolite can be metabolized by amide hydrolysis
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