346357
4′-(Trifluoromethyl)-2-biphenylcarboxylic acid
97%
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About This Item
Linear Formula:
CF3C6H4C6H4CO2H
CAS Number:
Molecular Weight:
266.22
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Product Name
4′-(Trifluoromethyl)-2-biphenylcarboxylic acid, 97%
InChI
1S/C14H9F3O2/c15-14(16,17)10-7-5-9(6-8-10)11-3-1-2-4-12(11)13(18)19/h1-8H,(H,18,19)
SMILES string
OC(=O)c1ccccc1-c2ccc(cc2)C(F)(F)F
InChI key
IQOMYCGTGFGDFN-UHFFFAOYSA-N
assay
97%
form
solid
mp
169-171 °C (lit.)
functional group
carboxylic acid
fluoro
Application
4′-(Trifluoromethyl)-2-biphenylcarboxylic acid may be used in chemical synthesis.
General description
4′-(Trifluoromethyl)-2-biphenylcarboxylic acid (xenalipin) has been tested as an effective hypolipidemic agent in animal species. It has been shown to cause significant reduction in serum cholesterol and triglyceride levels in animal models and would be beneficial in therapy for hyperlipidemia. Synthesis of 4′-(trifluoromethyl)-2-biphenylcarboxylic acid (xenalipin) has been reported. Xenalipin has been synthesized in the [14C]-labelled form, with specific activity 21.0mCi/mmol, which is suitable for the metabolism and distribution studies in animals.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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M C Lewis et al.
Atherosclerosis, 64(1), 27-35 (1987-03-01)
Xenalipin (4'-trifluoromethyl-2-biphenylcarboxylic acid) is a chemically novel compound which has been found to be an effective hypolipidemic agent in two animal species. Significant reductions in serum cholesterol and triglycerides were observed in cholesterol-cholic acid-fed rats following oral doses of 10-30
Synthesis of carbon-14 labelled xenalipin-a potential hypolipidemic agent.
Hill JA and Eaddy JF.
Journal of Labelled Compounds & Radiopharmaceuticals, 31(12), 1011-1017 (1992)
The Nickel (I) Catalyzed Coupling of a Diarylzinc with an Aryl Chloride in the Synthesis of Xenalipin.
Eaddy JF.
Organic preparations and procedures international, 27(3), 367-372 (1995)
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