358924
(+)-O,O′-Diacetyl-L-tartaric anhydride
97%
Synonym(s):
(+)-Diacetyl-L-tartaric anhydride
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About This Item
Empirical Formula (Hill Notation):
C8H8O7
CAS Number:
Molecular Weight:
216.14
UNSPSC Code:
12352005
NACRES:
NA.22
PubChem Substance ID:
EC Number:
228-502-7
Beilstein/REAXYS Number:
87315
MDL number:
Assay:
97%
Quality Level
assay
97%
optical activity
[α]20/D +59°, c = 6 in acetone
mp
130-135 °C (lit.)
functional group
anhydride, ester
storage temp.
2-8°C
SMILES string
CC(=O)O[C@@H]1[C@@H](OC(C)=O)C(=O)OC1=O
InChI
1S/C8H8O7/c1-3(9)13-5-6(14-4(2)10)8(12)15-7(5)11/h5-6H,1-2H3/t5-,6-/m1/s1
InChI key
XAKITKDHDMPGPW-PHDIDXHHSA-N
General description
(+)-O,O′-Diacetyl-L-tartaric anhydride is an HPLC derivatization reagent for UV/Vis detection. It is mainly employed as a reagent for the chiral derivatization of amino alcohols. It also reacts with alkanoamines in aprotic medium containing trichloroacetic acid and produces tartaric acid monoesters.
Application
(+)-O,O′-Diacetyl-L-tartaric anhydride may be used as a chiral derivatizating agent in the following:
- determination of enantiomeric vigabatrin in mouse serum samples using ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF-M)
- determination of trantinterol in rat plasma by ultra performance liquid chromatography–electrospray ionization mass spectrometry (UPLC–MS/MS)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Determination of enantiomeric vigabatrin by derivatization with diacetyl-l-tartaric anhydride followed by ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry
Zhao J, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1040, 199-207 (2017)
Enantioselective determination of trantinterol in rat plasma by ultra performance liquid chromatography?electrospray ionization mass spectrometry after derivatization
Yang J, et al.
Talanta, 79(5), 1204-1208 (2009)
W Lindner et al.
Journal of chromatography, 487(2), 375-383 (1989-02-24)
A sensitive high-performance liquid chromatographic method was developed for the stereoselective assay of (R)- and (S)-propranolol in human plasma. The method involves diethyl ether extraction of the drugs and a racemic internal standard, N-tert.-butylpropranolol, followed by derivatization of the compounds
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 358924-50G | 04061831812923 |