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361518

1-Hydroxypyrene

Name: 1-Hydroxypyrene
Brand: ALDRICH

98%

Synonym(s):

1-Pyrenol

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₀O

CAS Number:

5315-79-7

Molecular Weight:

218.25

NACRES:

NA.22

PubChem Substance ID:

24862229

UNSPSC Code:

12352100

MDL number:

MFCD00044543

Assay:

98%

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Properties

assay

98%

mp

179-182 °C (lit.)

SMILES string

Oc1ccc2ccc3cccc4ccc1c2c34

InChI

1S/C16H10O/c17-14-9-7-12-5-4-10-2-1-3-11-6-8-13(14)16(12)15(10)11/h1-9,17H

InChI key

BIJNHUAPTJVVNQ-UHFFFAOYSA-N

Description

General description

1-Hydroxypyrene, as a urinary metabolite, is a marker of polycyclic aromatic hydrocarbons (PAH) exposure. 1-Hydroxypyrene is an important biomarker of exposure to pyrene.

Application

1-Hydroxypyrene is suitable for use in following studies:

To investigate the fast detection and quantification of 1-hydroxypyrene in tissue extracts from Nereis diversicolor exposed to sediment-associated pyrene by a simple fluorometric method.
To investigate the effects of genetic polymorphisms of the cytochrome P450 1A1 (CYP1A1) and 2E1 (CYP2E1) and glutathione S-transferases mu (GSTM1) and theta (GSTT1) on urinary 1-hydroxypyrene and 2-naphthol levels in aircraft maintenance workers.
To examine the the PAH exposure of cokery workers in an Estonian oil shale processing plant.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Excretion profiles and half-lives of ten urinary polycyclic aromatic hydrocarbon metabolites after dietary exposure.

Zheng Li et al.

Chemical research in toxicology, 25(7), 1452-1461 (2012-06-06)

Human exposure to polycyclic aromatic hydrocarbons (PAHs) can be assessed by biomonitoring of their urinary monohydroxylated metabolites (OH-PAHs). Limited information exists on the human pharmacokinetics of OH-PAHs. This study aimed to investigate the excretion half-life of 1-hydroxypyrene (1-PYR), the most

Exposure to PAH compounds among cokery workers in the oil shale industry.

T Kuljukka et al.

Environmental health perspectives, 104 Suppl 3, 539-541 (1996-05-01)

The exposure of Estonian cokery workers to polynuclear aromatic hydrocarbons at an oil shale processing plant was assessed by occupational hygiene and biomonitoring measurements. To assess the external dose of exposure to polynuclear aromatic hydrocarbons, pyrene and benzo[a]pyrene concentrations were

Levels of 1-hydroxypyrene in urine of people living in an oil producing region of the Andean Amazon (Ecuador and Peru).

Jena Webb et al.

International archives of occupational and environmental health, 91(1), 105-115 (2017-09-25)

Polycyclic aromatic hydrocarbons (PAHs) are contaminants with carcinogenic effects but little is known about their presence in environments surrounding oil drilling operations and spills or exposure levels in nearby communities. The objective of this study was to characterize PAH levels

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Global Trade Item Number

SKU	GTIN
361518-100MG	04061831824278
361518-500MG	04061831824285