364878
1-Bromocarbonyl-1-methylethyl acetate
≥95.0%
Synonym(s):
α-Acetoxyisobutyryl bromide, 2-Acetoxy-2-methylpropionyl bromide
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About This Item
Linear Formula:
CH3COOC(CH3)2COBr
CAS Number:
Molecular Weight:
209.04
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
2432585
assay
≥95.0%
refractive index
n20/D 1.457 (lit.)
bp
75-77 °C/12 mmHg (lit.)
density
1.431 g/mL at 25 °C (lit.)
storage temp.
2-8°C
SMILES string
CC(=O)OC(C)(C)C(Br)=O
InChI
1S/C6H9BrO3/c1-4(8)10-6(2,3)5(7)9/h1-3H3
InChI key
OOKAXSHFTDPZHP-UHFFFAOYSA-N
General description
1-Bromocarbonyl-1-methylethyl acetate (α-Acetoxyisobutyryl bromide) participates in the conversion of adenosine to trans-3′(2′)-bromo-2′(3′)-acetates, via glycosyl cleavage.
Application
1-Bromocarbonyl-1-methylethyl acetate (α-Acetoxyisobutyryl bromide) may be used:
- in the chemoenzymatic synthesis of (1R,2S)-1,2-epoxy-1,2-dihydroacridine (acridine 1,2-oxide)
- in the synthesis of protected 3′-deoxyadenosine and 3′-deoxyguanosine
- as reagent for deoxygenation of vicinal diols, as well as in the preparation of 2′,3′-dideoxycytidine and other dideoxy and deoxynucleosides from the corresponding ribo series.
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B - STOT SE 3
target_organs
Respiratory system
supp_hazards
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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