365629
(S,S)-(+)-Tetrandrine
98%
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About This Item
Empirical Formula (Hill Notation):
C38H42N2O6
CAS Number:
Molecular Weight:
622.75
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
877811
SMILES string
COc1ccc2C[C@@H]3N(C)CCc4cc(OC)c(OC)c(Oc5cc6[C@H](Cc7ccc(Oc1c2)cc7)N(C)CCc6cc5OC)c34
assay
98%
optical activity
[α]20/D +285°, c = 1 in chloroform
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Li-Jun Peng et al.
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 30(1), 68-70 (2012-06-27)
To study the healing effect of pneumoconiosis with tetrandrine and massive whole-lung lavage. Choose 34 confirmed pneumoconiosis patients as drug treatment group and complex treatment group, and 17 tested workers as control group. Collected the content of TGF-beta1 and P
Tian Hu Wang et al.
Oncology reports, 28(5), 1681-1686 (2012-09-04)
Multidrug resistance is one of the major causes limiting the efficacy of chemotherapeutic agents to control esophageal cancer. Herein, we investigated that the effect and mechanism of tetrandrine (TET) in the human esophageal squamous carcinoma cisplatin-resistant cell line YES-2/DDP. The
Tatsuo Takahashi et al.
Biological & pharmaceutical bulletin, 35(10), 1765-1774 (2012-10-06)
One of the mediators of osteoclast differentiation is receptor activator of nuclear factor κB ligand (RANKL), which is produced by osteoblasts. Binding of RANKL to its receptor, RANK, activates several signaling pathways, including those involving mitogen-activated protein kinases (MAPKs), nuclear
Ping He et al.
Journal of Asian natural products research, 14(6), 564-576 (2012-05-17)
A series of new bisbenzylisoquinoline alkaloids was partially synthesized from tetrandrine and fangchinoline and evaluated for their ability to reverse P-glycoprotein-mediated multidrug resistance (MDR) in cancer cells. All the test compounds increased the intracellular accumulation rate of rhodamine 123 in
Tian-Tian Wang et al.
Zhongguo shi yan xue ye xue za zhi, 20(2), 246-251 (2012-05-01)
This study was aimed to investigate the effect of advanced glycosylation end products (AGE) on the proliferation of K562 and K562/A02 cells, the effect of tetrandrine (Tet) on proliferation of K562 and K562/A02 cells induced by AGE, and their mechanisms.
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