All Photos(1)

Documents

367710

Trichloroacetic anhydride

Name: Trichloroacetic anhydride
Brand: ALDRICH

technical grade, 95%

Sign Into View Organizational & Contract Pricing

All Photos(1)

Synonym(s):

(2,2,2-Trichloroacetyl) 2,2,2-trichloroacetate, Trichloroacetic acid anhydride

Linear Formula:

(Cl₃CCO)₂O

CAS Number:

4124-31-6

Molecular Weight:

308.76

Beilstein:

980355

EC Number:

223-925-3

MDL number:

MFCD00000793

PubChem Substance ID:

24862827

NACRES:

NA.22

grade

technical grade

Assay

95%

form

liquid

refractive index

n20/D 1.484 (lit.)

bp

139-141 °C/60 mmHg (lit.)

density

1.69 g/mL at 25 °C (lit.)

SMILES string

ClC(Cl)(Cl)C(=O)OC(=O)C(Cl)(Cl)Cl

InChI

1S/C4Cl6O3/c5-3(6,7)1(11)13-2(12)4(8,9)10

InChI key

MEFKFJOEVLUFAY-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

Organic Building Blocks

General description

Trichloroacetic anhydride is reported to be an efficient derivatization reagent, since it produces stable derivatives having both a higher mass fragmentation pattern and lesser volatility than derivatives of trifluoroacetic anhydride (TFAA) or heptafluorobutyric anhydride (HFBA). The interaction of thymidine 5′-phosphate with trichloroacetic anhydride in dimethylformamide and acetonitrile in the presence of tertiary amines hs been studied.

Application

Trichloroacetic anhydride may be used as derivatization reagent for the following studies:

Simultaneous analysis of amphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA or Ecstasy) in urine samples by solid-phase extraction, derivatization and gas chromatography/mass spectrometry.
Analysis of halogenated amphetamines in brain tissue from rats by gas chromatography with electron-capture detection (GC-ECD).
Quantitative determination of the metabolites of l-alpha-acetylmethadol (LAAM), such as noracetylmethadol, dinoracetylmethadol, methadol and normethadol by electron capture gas-liquid chromatography.

Pictograms

GHS05,GHS07

Signal Word

Danger

Hazard Statements

H302 - H314

Precautionary Statements

P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363

Hazard Classifications

Acute Tox. 4 Oral - Skin Corr. 1A

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

How to Find the Product Number

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503

Product Number

25G

Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

How to Find a Lot/Batch Number for COA

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').
For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').
For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Quantitation of methamphetamine and amphetamine in urine by capillary GC/MS Part II. Derivatization with 4-carbethoxyhexafluorobutyryl chloride.

R J Czarny et al.

Journal of analytical toxicology, 13(5), 257-262 (1989-09-01)

An analytical procedure for methamphetamine and amphetamine has been developed using 4-carbethoxyhexafluorobutyryl chloride. This derivatizing reagent has all the previously reported advantages of trichloroacetic anhydride (TCAA) in that it produces stable derivatives having both a higher mass fragmentation pattern and

Simultaneous analysis of amphetamine, methamphetamine, and 3, 4-methylenedioxymethamphetamine (MDMA) in urine samples by solid-phase extraction, derivatization, and gas chromatography/mass spectrometry.

B K Gan et al.

Journal of forensic sciences, 36(5), 1331-1341 (1991-09-01)

A rapid and effective solid-phase extraction procedure using Bond Elute Certify bonded silica sorbent cartridges was adopted to extract amphetamine, methamphetamine, and 3,4-methylenedioxymethamphetamine (MDMA or Ecstasy) from urine samples. The extract was derivatized with trichloroacetic anhydride prior to gas chromatography/mass

[Anhydride and halogenated-anhydride trihalogenacetic acid interaction with thymidine-5'-phosphate: ways to new activating reagents in nucleotide phosphorylation reactions].

V S Bogachev et al.

Bioorganicheskaia khimiia, 29(1), 64-74 (2003-03-28)

The interaction of thymidine 5'-phosphate with trichloroacetic anhydride, trichloroacetyl chloride, and tribromoacetyl bromide was studied in dimethylformamide and acetonitrile in the presence of tertiary amines. The first two reactions gave the mixed anhydride of trichloroacetic and thymidylic acids (acyl phosphate)

Comparative study on the derivatization of l-alpha-acetyl-methadol metabolites for electron capture gas-liquid chromatography.

D H Lau et al.

Journal of chromatography, 129, 329-338 (1976-12-22)

Six reagents-trichloroacetyl chloride, trichloroacetic anhydride, pentafluorobenzoyl chloride, heptafluorobutyryl chloride, heptafluorobutyric anhydride, and trifluoroacetic anhydride- were evaluated as potential derivatizing reagents for quantitating the metabolites of l-alpha-acetylmethadol (LAAM) -noracetylmethadol, dinoracetylmethadol, methadol, and normethadol-by electron capture gas-liquid chromatography. All of the reagents

Analysis of p-chloroamphetamine and a side-chain monofluorinated analogue in rat brain.

M L Owen et al.

Journal of pharmacological methods, 25(2), 147-155 (1991-04-01)

p-Chloro-alpha-fluoromethylphenylethylamine (fluoro-p-chloroamphetamine) (FpCA) has been shown in acute studies to be a less potent depletor of the neurotransmitter amine 5-hydroxytryptamine (5-HT) in brain than is p-chloroamphetamine (pCA). Gas chromatographic assay procedures for FpCA and PCA have been developed in our

View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service