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Merck
CN

368342

Azide exchange resin, azide on Amberlite IRA-400

16-50 mesh

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.22
MDL number:
Technical Service
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form

beads

reaction suitability

reaction type: solution phase peptide synthesis

particle size

16-50 mesh

capacity

3.8 mmol/g

Application

Azide exchange resin, azide on Amberlite IRA-400 is a resin commonly used to replace activated and nonactivated alkyl halides with azide functional group. It has been used in the synthesis of natural products (±)-oxomaritidine and nornicotine.
It can also be used to prepare:
  • Different imidazolium derived ionic liquid azides.
  • An azide synthon 1-(azidomethyl)-4-[18F]-fluorobenzene, which is used to label an amino acid and a neuropeptide using click chemistry.

Legal Information

Amberlite is a trademark of DuPont de Nemours, Inc.

pictograms

Skull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

supp_hazards

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Synthesis of nornicotine, nicotine and other functionalised derivatives using solid-supported reagents and scavengers
Baxendale IR, et al.
Journal of the Chemical Society. Perkin Transactions 1, 143-154 (2002)
Lars C Moeller et al.
Thyroid : official journal of the American Thyroid Association, 19(6), 639-644 (2009-05-19)
Knowledge on the action of thyroid hormone (TH) is augmented by the study of tissue responses to TH in vitro. In order to support the growth of cells in vitro, calf serum (CS) is usually added to the medium to
Hassner, A; Stern, M.
Angewandte Chemie (International Edition in English), 25, 478-478 (1986)
A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly
Baxendale IR, et al.
Chemical Communications (Cambridge, England), 2566-2568 (2006)
New strategy for the preparation of clickable peptides and labeling with 1-(azidomethyl)-4-[18F]-fluorobenzene for PET
Thonon D, et al.
Bioconjugate Chemistry, 20(4), 817-823 (2009)

Articles

Since the preparation of the first organic azide, phenyl azide, by Peter Griess in 1864 this energy-rich and versatile class of compounds has enjoyed considerable interest.

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