Skip to Content
Merck
CN

Key Documents

View All Documentation

368512

7-Hydroxy-4-(trifluoromethyl)coumarin

98%

Synonym(s):

4-(Trifluoromethyl)umbelliferone

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C10H5F3O3
CAS Number:
575-03-1
Molecular Weight:
230.14
UNSPSC Code:
12352103
NACRES:
NA.23
PubChem Substance ID:
24862915
MDL number:
MFCD00037578
Beilstein/REAXYS Number:
210932
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

assay

98%

form

solid

pKa 

7.26

mp

178-180 °C (lit.)

fluorescence

λex 385 nm; λem 502 nm in methanol

SMILES string

Oc1ccc2c(OC(=O)C=C2C(F)(F)F)c1

InChI

1S/C10H5F3O3/c11-10(12,13)7-4-9(15)16-8-3-5(14)1-2-6(7)8/h1-4,14H

InChI key

CCKWMCUOHJAVOL-UHFFFAOYSA-N

General description

7-Hydroxy-4-(trifluoromethyl)coumarin is a class of 7-hydroxycoumarin that is majorly used as laser dyes. It has a characterized emission spectra and may be used in excited state proton transfer (ESPT).

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCQ0127
MKCN6054
MKCM3164
MKCC3332
MKBX9560V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Sean Ekins et al.
Drug metabolism and disposition: the biological fate of chemicals, 31(9), 1077-1080 (2003-08-16)
CYP2D6 and CYP3A4 represent two particularly important members of the cytochrome p450 enzyme family due to their involvement in the metabolism of many commercially available drugs. Avoiding potent inhibitory interactions with both of these enzymes is highly desirable in early
Base-induced phototautomerization in 7-hydroxy-4-(trifluoromethyl) coumarin
Westlake BC, et al.
The Journal of Physical Chemistry B, 116(51), 14886-14891 (2012)
Hideto Jinno et al.
Drug metabolism and disposition: the biological fate of chemicals, 31(5), 528-532 (2003-04-16)
UDP-glucuronosyltransferase (UGT) 1A10 is an isoform of UGT1A, which is expressed in extrahepatic, biliary and aerodigestive/gastrointestinal tissues. We have previously reported two nonsynonymous single nucleotide polymorphisms in exon 1 of human UGT1A10 gene; 177G>A and 605C>T resulting in amino acid
View All Related Papers

Global Trade Item Number

SKUGTIN
368512-1G04061826662823
368512-250MG04061833482438