374334
1,1,1,2-Tetrafluoroethane
≥99%
Synonym(s):
HFC-134a
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About This Item
Linear Formula:
FCH2CF3
CAS Number:
Molecular Weight:
102.03
EC Number:
MDL number:
UNSPSC Code:
12142100
PubChem Substance ID:
NACRES:
NA.22
Assay
≥99%
bp
−26.5 °C (lit.)
functional group
fluoro
SMILES string
FCC(F)(F)F
InChI
1S/C2H2F4/c3-1-2(4,5)6/h1H2
InChI key
LVGUZGTVOIAKKC-UHFFFAOYSA-N
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General description
1,1,1,2-Tetrafluoroethane is used as a trifluorovinylating agent in organic synthesis. It is identified as a potential refrigerant used in place of chlorofluorocarbons. 1,1,1,2-Tetrafluoroethane can also be used as a solvent and medical propellant for a wide range of applications. It is used to extract materials of natural origin like natural flavors, fragrances, and nutraceuticals.
Application
1,1,1,2-Tetrafluoroethane can be used:
- As a solvent in the preparation of cross-linked polymer microspheres through the dispersion polymerization method.
- As a porogenic solvent in the preparation of porous polymethacrylate monolith via free radical polymerization.
- In the synthesis of trifluorovinyllithium, a key intermediate for the preparation of 2-halo-2,3-dideoxy-arabinose derivatives of biological importance.
Packaging
Supplied in a Sure/Pac™ cylinder and has a brass needle valve with a male 1/4" NPTF outlet thread installed. Before using the cylinder, ensure that the valve is closed, then remove the galvanized steel hex cap that seals the outlet valve.
Compatible with the following:
Compatible with the following:
Legal Information
Aldrich is a registered trademark of Sigma-Aldrich Co. LLC
Sure/Pac is a trademark of Sigma-Aldrich Co. LLC
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Press. Gas Compr. Gas
Storage Class Code
2A - Gases
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Yang Chen et al.
Pharmaceutical research, 32(9), 2928-2936 (2015-03-20)
This study investigated the effect of different active pharmaceutical ingredients (API) on aerosol electrostatic charges and aerosol performances for pressurized metered dose inhalers (pMDIs), using both insulating and conducting actuators. Five solution-based pMDIs containing different API ingredients including: beclomethasone dipropionate
Daniel Moraga-Espinoza et al.
International journal of pharmaceutics, 543(1-2), 376-385 (2018-04-11)
High-speed laser imaging (HSLI) is the preferred technique to characterize the geometry of the plume in pressurized metered dose inhalers (pMDIs). However, current methods do not allow for simulation of inhalation airflow and do not use drug mass quantification to
Lena Ernstgård et al.
Journal of applied toxicology : JAT, 30(1), 59-62 (2009-08-25)
Blood-air and tissue-blood coefficients (lambda) are essential to characterize the uptake and disposition of volatile substances, e.g. by physiologically based pharmacokinetic (PBPK) modelling. Highly volatile chemicals, including many hydrofluorocarbons (HFC) have low solubility in liquid media. These characteristics pose challenges
P D Levin et al.
British journal of anaesthesia, 92(6), 865-869 (2004-05-04)
1,1,1,2 Tetrafluoroethane is a hydrofluoroalkane (HFA) that is replacing chlorofluorocarbons (CFC) as a medical aerosol propellant in an attempt to reduce damage to the ozone layer. This study compared the effects of HFA- and CFC-based inhalers on four anaesthetic gas
1, 1, 1, 2-Tetrafluoroethane; from refrigerant and propellant to solvent
Corr S
Journal of Fluorine Chemistry, 118(1-2), 55-67 (2002)
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