376817
1-(2,3,5,6-Tetrafluorophenyl)imidazole
99%
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About This Item
Empirical Formula (Hill Notation):
C9H4F4N2
CAS Number:
Molecular Weight:
216.14
UNSPSC Code:
12352100
PubChem Substance ID:
MDL number:
SMILES string
Fc1cc(F)c(F)c(c1F)-n2ccnc2
assay
99%
mp
92-94 °C (lit.)
Regulatory Information
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Ana Paula Pereira da Silva et al.
The Biochemical journal, 417(3), 717-726 (2008-10-24)
3-BrPA (3-bromopyruvate) is an alkylating agent with anti-tumoral activity on hepatocellular carcinoma. This compound inhibits cellular ATP production owing to its action on glycolysis and oxidative phosphorylation; however, the specific metabolic steps and mechanisms of 3-BrPA action in human hepatocellular
Axel-R Hanauske et al.
Investigational new drugs, 27(4), 356-365 (2008-10-29)
The objectives of this phase I study were to determine the maximum tolerated dose (MTD), recommended phase II dose (RD), antitumor activity, safety, and pharmacokinetics of pemetrexed-paclitaxel combination. Patients (N = 95) with advanced solid tumors were assigned to three
Jihye Yun et al.
Science (New York, N.Y.), 325(5947), 1555-1559 (2009-08-08)
Tumor progression is driven by genetic mutations, but little is known about the environmental conditions that select for these mutations. Studying the transcriptomes of paired colorectal cancer cell lines that differed only in the mutational status of their KRAS or
Xiaodong Zhang et al.
Anticancer research, 29(4), 1443-1448 (2009-05-06)
Most cancer cells exhibit increased anaerobic glycolysis and use this metabolic pathway for the generation of ATP as a main source of energy. This impaired metabolism of glucose, leading to the secretion of lactic acid even in the presence of
Ji Su Kim et al.
Journal of bioenergetics and biomembranes, 40(6), 607-618 (2008-12-11)
Hexokinase type II (HK II) is the key enzyme for maintaining increased glycolysis in cancer cells where it is overexpressed. 3-bromopyruvate (3-BrPA), an inhibitor of HK II, induces cell death in cancer cells. To elucidate the molecular mechanism of 3-BrPA-induced
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