378623
2,4-Diaminopyrimidine
technical grade
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About This Item
Empirical Formula (Hill Notation):
C4H6N4
CAS Number:
Molecular Weight:
110.12
UNSPSC Code:
12352100
PubChem Substance ID:
EC Number:
205-862-3
MDL number:
InChI key
YAAWASYJIRZXSZ-UHFFFAOYSA-N
InChI
1S/C4H6N4/c5-3-1-2-7-4(6)8-3/h1-2H,(H4,5,6,7,8)
SMILES string
Nc1ccnc(N)n1
grade
technical grade
mp
143-147 °C (lit.)
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Christopher M Harris et al.
Bioorganic & medicinal chemistry letters, 20(1), 334-337 (2009-11-21)
We describe structure-based optimization of a series of novel 2,4-diaminopyrimidine MK2 inhibitors. Co-crystal structures (see accompanying Letter) demonstrated a unique inhibitor binding mode. Resulting inhibitors had IC(50) values as low as 19nM and moderate selectivity against a kinase panel. Compounds
Linda R Weinberg et al.
Bioorganic & medicinal chemistry letters, 21(1), 164-167 (2010-12-03)
The HGF-c-Met signaling axis is an important paracrine mediator of epithelial-mesenchymal cell interactions involving the regulation of multiple cellular activities including cell motility, mitogenesis, morphogenesis, and angiogenesis. Dysregulation of c-Met signaling (e.g., overexpression or increased activation) is associated with the
Michael D Serby et al.
Journal of medicinal chemistry, 49(8), 2568-2578 (2006-04-14)
Ghrelin, a gut-derived orexigenic hormone, is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R). Centrally administered ghrelin has been shown to cause hunger and increase food intake in rodents. Inhibition of ghrelin actions with ghrelin antibody, peptidyl GHS-R
Brian D Herman et al.
The Journal of biological chemistry, 285(16), 12101-12108 (2010-02-19)
The acyclic pyrimidine nucleoside phosphonate (ANP) phosphonylmethoxyethoxydiaminopyrimidine (PMEO-DAPym) differs from other ANPs in that the aliphatic alkyloxy linker is bound to the C-6 of the 2,4-diaminopyrimidine base through an ether bond, instead of the traditional alkyl linkage to the N-1
Daniel D Holsworth et al.
Bioorganic & medicinal chemistry letters, 17(13), 3575-3580 (2007-05-08)
Novel 2,4-diaminopyrimidine-based small molecule renin inhibitors are disclosed. Through high throughput screening, parallel synthesis, X-ray crystallography, and structure based drug design, we have developed the first non-chiral, non-peptidic, small molecular template to possess moderate potency against renin. The designed compounds
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