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Merck
CN

379395

Ethyl 1-piperidineacetate

98%

Synonym(s):

Piperidin-1-ylacetic acid ethyl ester

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About This Item

Empirical Formula (Hill Notation):
C9H17NO2
CAS Number:
23853-10-3
Molecular Weight:
171.24
NACRES:
NA.22
PubChem Substance ID:
24863628
UNSPSC Code:
12352100
MDL number:
MFCD00134496

Key Documents

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Product Name

Ethyl 1-piperidineacetate, 98%

InChI

1S/C9H17NO2/c1-2-12-9(11)8-10-6-4-3-5-7-10/h2-8H2,1H3

SMILES string

CCOC(=O)CN1CCCCC1

InChI key

LXZHLNWWDDNIOJ-UHFFFAOYSA-N

assay

98%

form

liquid

refractive index

n20/D 1.453 (lit.)

bp

109-111 °C/25 mmHg (lit.)

density

0.984 g/mL at 25 °C (lit.)

Application

Reactant for synthesis of:
Nicotinic acid receptor agonists for treatment of dyslipidemia
1-Alkylcyclanols with side chain functions
Benzhydrylamides for pharmacochemical studies

Reactant for:
Elimination reactions
Hydrogenation of esters to alcohols

General description

Ethyl 1-piperidineacetate (Piperidin-1-ylacetic acid ethyl ester) is an α-amino acid ethyl ester derivative. Thermal decomposition of ethyl 1-piperidineacetate in gas phase has been studied by ab initio theoretical methods. The kinetics of gas-phase decomposition of ethyl 1-piperidineacetate to the corresponding α-amino acid derivative and ethylene over the temperature range of 360-430°C and pressure range of 26-86Torr has been investigated. Alkylation reaction of ethyl 1-piperidineacetate with ethyl bromoacetate in absolute ethanol has been reported to obey second order kinetics.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

195.8 °F - closed cup

flash_point_c

91 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
S38316V
S38316
00623PC
00523PC
06421KY

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The mechanism of neutral amino acid decomposition in the gas phase. The elimination kinetics of N, N-dimethylglycine ethyl ester, ethyl 1-piperidineacetate, and N, N-dimethylglycine.
Ensuncho A, et al.
International Journal of Chemical Kinetics, 33(8), 465-471 (2001)
Theoretical study of the gas-phase decomposition of neutral α-amino acid ethyl esters. Part 2-Elimination of ethyl picolinate and ethyl 1-methylpipecolinate.
Notario R, et al.
Journal of Physical Organic Chemistry, 16(3), 166-174 (2003)
Alkylation of N-carbethoxy tertiary amines with ethyl bromoacetate.
Duty RC and Gurnea RL.
The Journal of Organic Chemistry, 35(6), 1800-1802 (1970)

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