Skip to Content
Merck
CN

Key Documents

View All Documentation

379492

1-Acetylindoline

98%

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C10H11NO
CAS Number:
16078-30-1
Molecular Weight:
161.20
NACRES:
NA.22
PubChem Substance ID:
24863664
UNSPSC Code:
12352100
MDL number:
MFCD00022908
Assay:
98%
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

assay

98%

mp

102-104 °C (lit.)

SMILES string

CC(=O)N1CCc2ccccc12

InChI

1S/C10H11NO/c1-8(12)11-7-6-9-4-2-3-5-10(9)11/h2-5H,6-7H2,1H3

InChI key

RNTCWULFNYNFGI-UHFFFAOYSA-N

General description

1-Acetylindoline, a substituted indole, is a tertiary amide having bulky N-groups. Its reduction to the corresponding amine, by reaction with silane in the presence of MoO2Cl2 (catalyst), has been reported.

Application

1-Acetylindoline may be used in the synthesis of 5-chloroindole.
  • Reactant for preparation of triazolothiadiazepine dioxide derivatives
  • Reactant for preparation of halo-substituted aromatic amides
  • Reactant for preparation of [[(phenyl)piperazinyl]alkyl]indolyl]ethanone and [[[(phenoxyethyl)piperazinyl]alkyl]indolyl]ethanone derivatives as α1-adrenoreceptor antagonists
  • Reactant for synthesis of naphthalenedione derivatives as antimycobacterial agents
  • Reactant for regioselective ortho Suzuki-Miyaura coupling reaction

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
03430PH
13805MN
10015MQ
13012PU
09914EY

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Reduction of amides with silanes catalyzed by MoO2Cl2.
Fernandes AC and Rom?o CC.
J. Mol. Catal. A: Chem., 272(1), 60-63 (2007)
Highly Convenient and Large Scale Synthesis of 5-chloroindole and its 3-substituted Analogues
Keetha L, et al.
J. Korean Chem. Soc., 55(2) (2011)
The synthesis of 5-and 7-acetylindole derivatives. I: The photochemical rearrangement of 1-acetylindoline.
Akagi M and Ozaki K.
Heterocycles, 26(!), 61-64 (1987)

Global Trade Item Number

SKUGTIN
379492-5G04061832841670