38130
3,5-Diiodo-L-tyrosine dihydrate
≥98.0% (NT)
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About This Item
Empirical Formula (Hill Notation):
C9H9I2NO3 · 2H2O
CAS Number:
Molecular Weight:
469.01
PubChem Substance ID:
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
2218691
MDL number:
SMILES string
N[C@@H](Cc1cc(I)c(O)c(I)c1)C(O)=O
InChI
1S/C9H9I2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1
InChI key
NYPYHUZRZVSYKL-ZETCQYMHSA-N
assay
≥98.0% (NT)
optical activity
[α]20/D +1.2±0.4°, c = 5% in 1 M HCl
mp
199-201 °C (dec.), 200 °C (dec.) (lit.)
storage temp.
2-8°C
Other Notes
Intermediate in the biosynthesis and alternative pathways of metabolism of thyroid hormones. Substrate for the assay of halogenated tyrosine and thyroid hormone aminotransferase
Regulatory Information
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A Balsam et al.
The Journal of clinical investigation, 72(4), 1234-1245 (1983-10-01)
Studies were performed to elucidate the nature of the pathway of hepatic thyroxine (T4) metabolism that is activated by inhibitors of liver catalase. For this purpose, the metabolism of T4 in homogenates of rat liver was monitored with T4 labeled
Purification and properties of halogenated tyrosine and thyroid hormone transaminase from rat kidney mitochondria.
M Nakano
The Journal of biological chemistry, 242(1), 73-81 (1967-01-10)
M. Nakano
Methods in Enzymology, 17A, 660-660 (1970)
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