382256
4-Hydroxy-8-(trifluoromethyl)quinoline
98%
Synonym(s):
8-(Trifluoromethyl)-4-quinolinol
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About This Item
Empirical Formula (Hill Notation):
C10H6F3NO
CAS Number:
Molecular Weight:
213.16
UNSPSC Code:
12352100
PubChem Substance ID:
EC Number:
245-879-3
MDL number:
Assay:
98%
assay
98%
mp
174-176 °C (lit.)
SMILES string
Oc1ccnc2c(cccc12)C(F)(F)F
InChI
1S/C10H6F3NO/c11-10(12,13)7-3-1-2-6-8(15)4-5-14-9(6)7/h1-5H,(H,14,15)
InChI key
UDRWADJLLWWJOE-UHFFFAOYSA-N
General description
4-Hydroxy-8-(trifluoromethyl)quinolone (8-(Trifluoromethyl)-4-quinolinol) is a heterocyclic building block. Various 4-hydroxy-8-trifluoromethyl-quinoline derivatives have been prepared via multi step reactions and were tested for their antimicrobial actions.
Application
4-Hydroxy-8-(trifluoromethyl)quinolone (4-Hydroxy-8-trifluoromethylquinolone) may be used in the synthesis of analgesic compound, floctafenine.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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William Andrew Publishing
Pharmaceutical Manufacturing Encyclopedia, 4, 1621-1621 (2013)
K D Thomas et al.
European journal of medicinal chemistry, 46(11), 5283-5292 (2011-09-13)
Three new series of 4-hydroxy-8-trifluoromethyl-quinoline derivatives were synthesized through multi step reactions. All the newly synthesized compounds were characterized by spectral and elemental analyses. The structure of 5j was evidenced by X-ray crystallographic study. The newly synthesized title compounds were