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Merck
CN

385344

4-Hydroxy-6-(trifluoromethyl)pyrimidine

99%

Synonym(s):

6-(Trifluoromethyl)-4-pyrimidinol

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About This Item

Empirical Formula (Hill Notation):
C5H3F3N2O
CAS Number:
1546-78-7
Molecular Weight:
164.09
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24864019
MDL number:
MFCD00192530
Beilstein/REAXYS Number:
145548
Assay:
99%

Key Documents

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Product Name

4-Hydroxy-6-(trifluoromethyl)pyrimidine, 99%

InChI

1S/C5H3F3N2O/c6-5(7,8)3-1-4(11)10-2-9-3/h1-2H,(H,9,10,11)

SMILES string

Oc1cc(ncn1)C(F)(F)F

InChI key

LVOYSBZJJWPUBD-UHFFFAOYSA-N

assay

99%

mp

169-171 °C (lit.)

functional group

fluoro

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Application

4-Hydroxy-6-(trifluoromethyl)pyrimidine (6-(Trifluoromethyl)-4-pyrimidinol) may be used in the synthesis of 10-[3-(6-trifluoromethyl-pyrimidin-4-yloxy)-propoxy]-(20S)-camptothecin.

General description

4-Hydroxy-6-(trifluoromethyl)pyrimidine, a pyrimidine derivative, is a heterocyclic building block.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
S72095V
S58342V
S72095
01129JJ
S58342

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Qingyong Li et al.
Bioorganic & medicinal chemistry, 14(21), 7175-7182 (2006-07-28)
In an attempt to improve the antitumor activity and decrease the cytotoxicity of camptothecin, 18 new 10-substituted camptothecin derivatives were prepared. The cytotoxicity in vitro on cancer cell lines and antitumor activity in vivo, and inhibitory properties of topoisomerase I

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