391468
4-Hydroxypiperidine hydrochloride
98%
Synonym(s):
4-Piperidinol hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C5H11NO · HCl
CAS Number:
Molecular Weight:
137.61
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
226-374-7
Beilstein/REAXYS Number:
3908995
MDL number:
Assay:
98%
InChI key
VKCORPXOKYDINR-UHFFFAOYSA-N
InChI
1S/C5H11NO.ClH/c7-5-1-3-6-4-2-5;/h5-7H,1-4H2;1H
SMILES string
Cl[H].OC1CCNCC1
assay
98%
solubility
methanol: soluble 25 mg/mL, clear, colorless
functional group
hydroxyl
General description
4-Hydroxypiperidine hydrochloride is a piperidine derivative. The synthesis of 4-hydroxypiperidine has been reported. 4-Hydroxypiperidine participates in the synthesis of 4-(4′-hydroxypiperidino)-4-phenylcyclohexanol and 1-(4-hydroxypiperidino)cyclohexanecarbonitrile. 4-Hydroxypiperidine is the starting material for the synthesis of Sibrafiban and Lamifiban, two non-peptidefibrinogen receptor.
Application
4-Hydroxypiperidine hydrochloride is suitable for use in the Ugi-multi component reaction (MCR) to study the use of miniaturised-synthesis and Total Analysis System (mSYNTAS) in solution phase synthesis and on-line analysis of Ugi-MCRs. It may be used in the synthesis of acetic acid-piperidine-4-yl ester.
Reactant for synthesis of:
14C-labeled E4010
PET tracer for imaging brain acetylcholinesterase
Reactant for allosteric modulators of metabotropic glutamate receptor subtype 5
14C-labeled E4010
PET tracer for imaging brain acetylcholinesterase
Reactant for allosteric modulators of metabotropic glutamate receptor subtype 5
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Concise Synthesis of Sibrafiban and Lamifiban, Two Non-Peptide Fibrinogen Receptor (GPIIb/IIIa) Antagonists.
Chang MY and Chen ST.
J. Chin. Chem. Soc., 48(2), 133-135 (2001)
Synthesis of 4-(4'-hydroxypiperidino)-4-phenylcyclohexanol, a dihydroxy phencyclidine metabolite.
Brine GA, et al.
Organic preparations and procedures international, 15(6), 371-377 (1983)
The Synthesis of Δ3-Tetrahydropyridine.
Renshaw RR and Conn RC.
Journal of the American Chemical Society, 60(4), 745-747 (1938)
C Deleuze-Masquefa et al.
Journal of medicinal chemistry, 40(25), 4019-4025 (1997-12-24)
1-[1-(2-Benzo[b]thiopheneyl)cyclohexyl]piperidine hydrochloride (BTCP, 1) and cocaine bind to the neuronal dopamine transporter to inhibit dopamine (DA) reuptake. However, on chronic administration, cocaine produces sensitization, but 1 produces tolerance. Because metabolites of 1 might be responsible for some of its pharmacological
M C Mitchell et al.
The Analyst, 126(1), 24-27 (2001-02-24)
A miniaturised-SYNthesis and Total Analysis System (mu SYNTAS) was used for the solution-phase synthesis and on-line analysis (TOF-MS) of Ugi multicomponent reaction (MCR) products. This approach provides an unusually high degree of control of the MCR and delivers detailed, novel
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