404357
2,4,5-Trifluorobenzoyl chloride
97%
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About This Item
Linear Formula:
F3C6H2COCl
CAS Number:
Molecular Weight:
194.54
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
3606259
assay
97%
form
liquid
refractive index
n20/D 1.498 (lit.)
density
1.52 g/mL at 25 °C (lit.)
SMILES string
Fc1cc(F)c(cc1F)C(Cl)=O
InChI
1S/C7H2ClF3O/c8-7(12)3-1-5(10)6(11)2-4(3)9/h1-2H
InChI key
STBGCAUUOPNJBH-UHFFFAOYSA-N
General description
2,4,5-Trifluorobenzoyl chloride is an aryl fluorinated building block.
Application
2,4,5-Trifluorobenzoyl chloride may be used in the synthesis of several glycosylated derivatives of some fluoroquinolone antibiotics. It may be employed in one-pot synthesis of ethyl 8,9-difluoro-6-oxo-6H-benzo[c]quinolizine-5-carboxylate.
signalword
Danger
hcodes
Hazard Classifications
Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
186.8 °F - closed cup
flash_point_c
86 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Regulatory Information
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M E Jung et al.
Journal of medicinal chemistry, 42(19), 3899-3909 (1999-10-03)
We report herein the synthesis and biological testing of several glycosylated derivatives of some fluoroquinolone antibiotics. In particular, we have prepared several glycosylated derivatives of ciprofloxacin (2) in which the carbohydrate units are linked to the free secondary amine of
The synthesis and biological activity of 8-fluoro-9-(4-methyl-1-piperazinyl)-6-oxo-6H-benzo[c]quinolizine-5-carboxylic acid.
Ziegler B, et al.
Journal of Medicinal Chemistry, 27(3), 587-589 (1990)
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