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404888

1-Methyl-2-phenylindole

Name: 1-Methyl-2-phenylindole
Brand: ALDRICH

99%

Synonym(s):

NSC 63793

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₃N

CAS Number:

3558-24-5

Molecular Weight:

207.27

NACRES:

NA.22

PubChem Substance ID:

24865277

UNSPSC Code:

12352100

EC Number:

222-618-1

MDL number:

MFCD00022892

Assay:

99%

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Properties

Quality Level

100

assay

99%

mp

98-100 °C (lit.)

functional group

phenyl

SMILES string

Cn1c(cc2ccccc12)-c3ccccc3

InChI

1S/C15H13N/c1-16-14-10-6-5-9-13(14)11-15(16)12-7-3-2-4-8-12/h2-11H,1H3

InChI key

SFWZZSXCWQTORH-UHFFFAOYSA-N

Description

General description

Reaction of 1-methyl-2-phenylindole with nitrogen dioxide or with nitrous acid (NaNO₂-CH₃COOH) in benzene has been studied. 1-Methyl-2-phenylindole is reported to react with malondialdehyde (MDA) and 4-hydroxyalkenals to afford a stable chromophore with intense maximal absorbance at 586nm.

Application

1-Methyl-2-phenylindole may be used in the following studies:

The estimation of lipid peroxidation in third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg.
As chromogenic agent for the determination of estimation of malondialdehyde (MDA) production.
Colorimetric assay of lipid peroxidation.
Synthesis of 1-methyl-2-phenyl-3-(1,3,4-thiadiazol-2-yldiazenyl)-1H-indole.
Synthesis of 3-(5-ethyl-1,3,4-thiadiazol-2-yldiazenyl)-1-methyl-2-phenyl-1H-indole.

Reactant for preparation of:

Cyano indoles
Difluorohydroxy indoles

Reactant for:

Carboxylation of indoles
Allylation of indoles
Formylation of indoles
Nitrosylation of indoles

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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1-Methyl-2-phenyl-3-(1, 3, 4-thiadiazol-2-yldiazenyl)-1H-indole.

Seferoglu Z, et al.

Acta Crystallographica Section E, Structure Reports Online, 63(1), 148-150 (2007)

The single IGF-1 partial deficiency is responsible for mitochondrial dysfunction and is restored by IGF-1 replacement therapy.

M Olleros Santos-Ruiz et al.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 35, 21-32 (2017-06-27)

We previously described in cirrhosis and aging, both conditions of IGF-1 deficiency, a clear hepatic mitochondrial dysfunction with increased oxidative damage. In both conditions, the hepatic mitochondrial function was improved with low doses of IGF-1. The aim of this work

Effect of Forced Physical Activity on the Severity of Experimental Colitis in Normal Weight and Obese Mice. Involvement of Oxidative Stress and Proinflammatory Biomarkers.

Jan Bilski et al.

Nutrients, 11(5) (2019-05-24)

Inflammatory bowel diseases are a heterogeneous group of disorders represented by two major phenotypic forms, Crohn's disease and ulcerative colitis. Cross talk between adipokines and myokines, as well as changes in intestinal microcirculation, was proposed in pathogenesis of these disorders.

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Global Trade Item Number

SKU	GTIN
404888-10G	04061831987058