405760
Ethyl 2-oxo-1-cyclooctanecarboxylate
97%
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About This Item
Linear Formula:
(O=)C8H13CO2C2H5
CAS Number:
Molecular Weight:
196.24
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
97%
Form:
liquid
InChI
1S/C11H18O3/c1-2-14-11(13)9-7-5-3-4-6-8-10(9)12/h9H,2-8H2,1H3
SMILES string
CCOC(=O)C1CCCCCCC1=O
InChI key
OJCDCHCBNASPBS-UHFFFAOYSA-N
assay
97%
form
liquid
refractive index
n20/D 1.483 (lit.)
bp
85-87 °C/0.1 mmHg (lit.)
density
1.04 g/mL at 25 °C (lit.)
General description
Ethyl 2-oxo-1-cyclooctanecarboxylate (2-carbethoxycyclooctanone) is a β-keto ester. It undergoes Michael addition with 3-buten-2-one (methyl vinyl ketone, MVK) in the presence of potassium bis(1,2-benzenediolato)phenylsilicate to afford the corresponding 1,4-adduct. It can be synthesized from cycloheptanone. Its boiling point, density and refractive index have been determined.
Application
Ethyl 2-oxo-1-cyclooctanecarboxylate (2-carbethoxycyclooctanone) may be used in the synthesis of 2-carbethoxy-2-cyclooctenone.
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
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Activated cyclooctenones are effective dienophiles.
Liu HJ, et al.
Canadian Journal of Chemistry, 75(6), 899-912 (1997)
Yaws CL.
The Yaws Handbook of Physical Properties for Hydrocarbons and Chemicals, 336-336 (2015)
Pentacoordinate Organosilicate-Catalyzed Michael Addition of ?-Keto Esters to 3-Buten-2-one.
Tateiwa J-U and Hosomi A.
European Journal of Organic Chemistry, 2001(8), 1445-1448 (2001)
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