411035
6-Hydroxyflavone
98%
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About This Item
Empirical Formula (Hill Notation):
C15H10O3
CAS Number:
Molecular Weight:
238.24
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
229-704-8
MDL number:
Product Name
6-Hydroxyflavone, 98%
assay
98%
form
solid
InChI key
GPZYYYGYCRFPBU-UHFFFAOYSA-N
InChI
1S/C15H10O3/c16-11-6-7-14-12(8-11)13(17)9-15(18-14)10-4-2-1-3-5-10/h1-9,16H
SMILES string
Oc1ccc2OC(=CC(=O)c2c1)c3ccccc3
mp
234-236 °C (lit.)
functional group
ketone
phenyl
Quality Level
Gene Information
rat ... Ar(24208), Gabra2(29706)
Related Categories
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Structure of 6-hydroxyflavone.
Seetharaman J and Rajan SS.
Acta Crystallographica Section C, Structural Chemistry, 48(9), 1714-1715 (1992)
Chien-Hung Lai et al.
Evidence-based complementary and alternative medicine : eCAM, 2014, 924560-924560 (2014-05-06)
Osteoblast differentiation plays an essential role in bone integrity. Isoflavones and some flavonoids are reported to have osteogenic activity and potentially possess the ability to treat osteoporosis. However, limited information concerning the osteogenic characteristics of hydroxyflavones is available. This study
A novel and facile iodine (III)-mediated approach for C (5)-acetoxylation of 6-hydroxyflavone and 6-hydroxyflavanones.
Prakash O, et al.
Tetrahedron Letters, 45(49), 9065-9067 (2004)
Angélica Flores-Flores et al.
Drug development research, 80(2), 218-229 (2018-11-06)
Previously, we described tracheal rat rings relaxation by several flavonoids, being 6-hydroxyflavone (6-HOF) the most active derivative of the series. Thus, its mechanism of action was determined in an ex vivo tracheal rat ring bioassay. The anti-asthmatic effect was assayed
Xing Wang et al.
PloS one, 10(3), e0116409-e0116409 (2015-03-20)
Inflammatory responses by kidney mesangial cells play a critical role in the glomerulonephritis. The anti-inflammatory potential of nineteen mono-, di- and polyhydroxylated flavones including fisetin, quercetin, morin, tricetin, gossypetin, apigenin and myricetin were investigated on rat mesangial cells with lipopolysaccharide
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