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421235

1-(2-Pyrimidyl)piperazine

Name: 1-(2-Pyrimidyl)piperazine
Brand: ALDRICH

98%

Synonym(s):

2-(1-Piperazinyl)pyrimidine

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₂N₄

Molecular Weight:

164.21

NACRES:

NA.22

PubChem Substance ID:

24866373

UNSPSC Code:

12352100

EC Number:

244-135-5

MDL number:

MFCD00040742

Assay:

98%

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Properties

assay

98%

refractive index

n20/D 1.587 (lit.)

bp

277 °C (lit.)

density

1.158 g/mL at 25 °C (lit.)

SMILES string

C1CN(CCN1)c2ncccn2

InChI

1S/C8H12N4/c1-2-10-8(11-3-1)12-6-4-9-5-7-12/h1-3,9H,4-7H2

InChI key

MRBFGEHILMYPTF-UHFFFAOYSA-N

Description

General description

1-(2-Pyrimidyl)piperazine is a piperazine-based derivative. It is a metabolite of buspirone.

Application

1-(2-Pyrimidyl)piperazine may be used for the following studies:

As derivatization reagent for the carboxyl groups on peptides.
Carboxy group derivatization during the spectrophotometric analysis of phosphopeptides.
Starting reagent for the synthesis of 3-{(4-(pyrimidin-2-yl)piperazin-1-yl)methyl}-1H-pyrrolo[2,3-b]pyridine.
Synthesis of 3-phenyl-6-(4-(pyrimidin-2-yl)piperazin-1-yl)pyridazin-4-ol.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

>230.0 °F

flash_point_c

> 110 °C

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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The influence of buspirone, and its metabolite 1-PP, on the activity of paroxetine in the mouse light/dark paradigm and four plates test.

M Hascoët et al.

Pharmacology, biochemistry, and behavior, 67(1), 45-53 (2000-12-13)

Although numerous animal procedures have been employed in the study of antidepressants (ADs) in anxiety, the results following acute administration remain highly variable. The present study investigated the effect of the SSRI paroxetine (4, 8, and 16 mg/kg, IP) in

Piperazines for peptide carboxyl group derivatization: effect of derivatization reagents and properties of peptides on signal enhancement in matrix-assisted laser desorption/ionization mass spectrometry.

Xiaoqiang Qiao et al.

Rapid communications in mass spectrometry : RCM, 25(5), 639-646 (2011-02-04)

Piperazine-based derivatives, including 1-(2-pyridyl)piperazine (2-PP), 1-(2-pyrimidyl)piperazine (2-PMP), 1-(4-pyridyl)piperazine (4-PP), and 1-(1-methyl-4-piperidinyl)piperazine (M-PP), were used for the derivatization of carboxyl groups on peptides with 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and 1-hydroxy-7-azabenzotriazole (HOAt) as coupling reagents, and trifluoroacetic acid (TFA) as activator. Taking synthetic

Interactions of buspirone with itraconazole and rifampicin: effects on the pharmacokinetics of the active 1-(2-pyrimidinyl)-piperazine metabolite of buspirone.

K T Kivistö et al.

Pharmacology & toxicology, 84(2), 94-97 (1999-03-06)

The effects of inhibition and induction of the metabolism of buspirone on the plasma concentrations of 1-(2-pyrimidinyl)-piperazine (a piperazine metabolite), the principal active metabolite of buspirone, were investigated. Two separate randomized, placebo-controlled cross-over studies with two phases were carried out

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Global Trade Item Number

SKU	GTIN
421235-25G	04061833389775
421235-5G	04061832093734