422916
2-Methoxy-4-nitrobenzoic acid
98%
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About This Item
Linear Formula:
CH3OC6H3(NO2)CO2H
CAS Number:
Molecular Weight:
197.14
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
219-998-6
MDL number:
Assay:
98%
Product Name
2-Methoxy-4-nitrobenzoic acid, 98%
InChI key
KPJXEWJRJKEOCD-UHFFFAOYSA-N
InChI
1S/C8H7NO5/c1-14-7-4-5(9(12)13)2-3-6(7)8(10)11/h2-4H,1H3,(H,10,11)
SMILES string
COc1cc(ccc1C(O)=O)[N+]([O-])=O
assay
98%
mp
146-148 °C (lit.)
functional group
carboxylic acid
nitro
Quality Level
Related Categories
Application
2-Methoxy-4-nitrobenzoic acid may be used as a starting material in the following syntheses:
- 2-Methoxy-4-nitrobenzamide, a nitroamide derivative.
- 4-Amino-2-methoxybenzamide, an aminobenzamide derivative.
- N,2-Dimethoxy-N-methyl-4-nitrobenzamide, a Weinreb amide derivative.
- 1-(2-Methoxy-4-nitrophenyl)-5-methylhex-2-yn-1-one, a ynone derivative.
- 2,5-Constrained piperidine derivative, a potential CCR3 (Chemokine (C-C Motif) Receptor 3) antagonist.
General description
2-Methoxy-4-nitrobenzoic acid is an alkoxybenzoic acid derivative. It has been reported to be synthesized by reacting 2-hydroxy-4-nitrobenzoic acid with methyl iodide and characterized by 1H and 13C-NMR spectra.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Leyi Gong et al.
Bioorganic & medicinal chemistry letters, 13(20), 3597-3600 (2003-09-25)
As part of our investigation into the development of potent CCR3 antagonists, a series of piperidine analogues was designed and prepared. Exploration of the piperidine core examined both the basicity and the location of a nitrogen, as well as conformational
Marc J Adler et al.
The Journal of organic chemistry, 76(17), 7040-7047 (2011-07-12)
The design and synthesis of small molecule α-helix mimetics has been a productive field over the past decade. These compounds have performed well in a variety of biological systems as functional disruptors of α-helix-mediated protein-protein interactions. In our studies we
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